The formation of multicomponent and bioactive supramolecular polymers is a promising strategy for the formation of biomaterials that match the dynamic and responsive nature of biological systems. In order to fully realize the potential of this strategy, knowledge of the location and behavior of bioactive components within the system is crucial. By employing synthetic strategies to create multifunctional monomers, coupled with FRET and STORM techniques, we have investigated the formation and behavior of a bioactive and multicomponent supramolecular polymer. By creating a peptide-dye-monomer conjugate, we were able to measure high degrees of monomer incorporation and to visualize the equal distribution of monomers within the supramolecular polymer. Furthermore, by tracking the movement of monomers, we uncovered small differences in the dynamics of the bioactive monomers.
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Article Synopsis
- Peptide building blocks can create supramolecular nanostructures that effectively deliver various drugs while their design impacts the ability of these structures to interact with specific drugs.
- The study focuses on hybrid cationic peptide hydrogels, combining a low-molecular-weight hydrogelator with different cationic amphiphilic peptides to analyze their structural properties.
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