AI Article Synopsis
- * Three strains of S. epidermidis were analyzed: the first was sensitive to linezolid, while two strains isolated after treatment showed reduced susceptibility and resistance to linezolid.
- * Genetic mutations associated with resistance were identified in the strains, highlighting that linezolid-resistant infections, although uncommon, can arise after extended treatment with the drug.
Article Abstract
We report an 8-year-old patient with catheter-related bacteremia caused by linezolid-resistant Staphylococcus epidermidis that was isolated after the long-term, repeated use of linezolid. Three S. epidermidis strains isolated from this patient were bacteriologically analyzed. While the strain isolated prior to linezolid initiation was susceptible to linezolid, two strains after linezolid therapy displayed low-level linezolid susceptibility (MIC, 4 mg/L) and linezolid resistance (MIC, 16 mg/L). T2500A mutation in two copies and G2575T mutations in three copies of 23S rRNA were detected in the low-susceptible strain and the resistant strain, respectively. Linezolid-resistant S. epidermidis infection is rare, but may occur with the long-term administration of linezolid.
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| http://dx.doi.org/10.1016/j.jiac.2015.10.004 | DOI Listing |
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