Objective: The aim of the present study was to determine the use of static and dynamic haemodynamic parameters for predicting fluid responsiveness prior to volume expansion (VE) in intensive care unit (ICU) patients with systemic inflammatory response syndrome (SIRS).
Methods: We conducted a prospective, multicentre, observational study in 6 French ICUs in 2012. ICU physicians were audited concerning their use of static and dynamic haemodynamic parameters before each VE performed in patients with SIRS for 6 consecutive weeks.
Results: The median volume of the 566 VEs administered to patients with SIRS was 1000mL [500-1000mL]. Although at least one static or dynamic haemodynamic parameter was measurable before 99% (95% CI, 99%-100%) of VEs, at least one them was used in only 38% (95% CI, 34%-42%) of cases: static parameters in 11% of cases (95% CI, 10%-12%) and dynamic parameters in 32% (95% CI, 30%-34%). Static parameters were never used when uninterpretable. For 15% of VEs (95% CI, 12%-18%), a dynamic parameter was measured in the presence of contraindications. Among dynamic parameters, respiratory variations in arterial pulse pressure (PPV) and passive leg raising (PLR) were measurable and interpretable before 17% and 90% of VEs, respectively.
Conclusions: Haemodynamic parameters are underused for predicting fluid responsiveness in current practice. In contrast to static parameters, dynamic parameters are often incorrectly used in the presence of contraindications. PLR is more frequently valid than PPV for predicting fluid responsiveness in ICU patients.
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http://dx.doi.org/10.1016/j.accpm.2015.08.003 | DOI Listing |
J Biomol Struct Dyn
December 2024
School of Physical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, Maharashtra, India.
The dielectric behavior of Asparagine (CHNO) in water over the frequency range of 10 MHz to 30 GHz in the temperature region of 278.15-303.15 K in a step of 5 K has been carried out using time domain reflectometry (TDR) at various concentrations of asparagine.
View Article and Find Full Text PDFFEMS Microbiol Lett
December 2024
Laboratory of Transcription, Center for DNA Fingerprinting and Diagnostics, Inner Ring Road, Uppal, Hyderabad, India-500039.
Bacterial transcription terminator, Rho is an RNA-dependent ATPase that terminates transcription. Several structures of pre-termination complexes of the Rho-transcription elongation complex (EC) revealed a static picture of components of the EC that come close to the nascent RNA-bound Rho, where many of the residues of EC reside ≤ 10 Å from the Rho residues. However, the in vitro-formed Rho-EC complexes do not reveal the in vivo Rho-EC dynamic interaction patterns during the termination process.
View Article and Find Full Text PDFHealth Place
December 2024
University of South Carolina,United States.
Despite a large body of work on neighborhood effects on health, past studies are limited in their treatment of neighborhoods as largely static spaces with (dis)advantages based primarily on the average characteristics of their residents. In this study, we draw on the triple neighborhood disadvantage perspective to explore how socioeconomic disadvantage in a neighborhood's mobility network uniquely relates to children's overall health levels, independent of residential disadvantage. We investigate this by combining 2019 SafeGraph data on mobility patterns from roughly 40 million U.
View Article and Find Full Text PDFPLoS One
December 2024
Section of Rehabilitation in Orthopaedics, Clinical Rehabilitation Institute, Faculty of Motor Rehabilitation, University of Physical Education, Krakow, Poland.
Background: Postural stability is essential for functional independence in the pregnant population. The contradictions between existing studies and the lack of consistent characteristics in the strategies used by pregnant women for postural control demonstrate the need for further investigation.
Objectives: The aim was to review the available literature on postural strategies throughout pregnancy in both static and dynamic conditions and to provide an assessment of the quality of these studies in terms of methodological issues to identify the reasons for the inconsistencies in findings between research centers.
Int Arch Occup Environ Health
December 2024
Social Science and Occupational Health Research Group, National Institute of Occupational Safety and Health, Nagao 6-21-1, Tama-Ku, Kawasaki, 214-8585, Japan.
Purpose: We estimated the static and dynamic effects of promotion to managerial positions on mental health and satisfaction using the recent estimation method; we addressed the gap in extant research by considering the heterogeneity in treatment timing to reconfirm evidence regarding the causal effects of promotion.
Methods: We used a modified estimation method of two-way fixed effects recommended by (Callaway and Sant'Anna, J Econom 225:200-230, 2021). To check for robustness, we compared the analyses using propensity sample matching, an alternative treatment timing heterogeneity-robust analysis, and a normal two-way fixed effects event study.
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