AI Article Synopsis
- A new method for amination of tryptamines using DPH and a CuBr-bisoxazoline catalyst was developed, leading to compounds called 3a-amino-pyrroloindolines with high enantioselectivity.
- This reaction occurs under mild conditions, making it a potentially practical approach in organic synthesis.
- The method was successfully applied in the total synthesis of (-)-psychotriasine, showing its synthetic utility and efficiency.
Article Abstract
A direct asymmetric dearomative amination of tryptamines with O-(2,4-dinitrophenyl)hydroxylamine (DPH) was achieved using CuBr-bisoxazoline complex as a catalyst, affording 3a-amino-pyrroloindolines in good to excellent enantioselectivity under mild reaction conditions. Furthermore, the synthetic value of this method was demonstrated in the total synthesis of (-)-psychotriasine in a highly concise manner.
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| http://dx.doi.org/10.1002/anie.201508570 | DOI Listing |
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