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Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions. | LitMetric
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Role of PI3K, ERK, and p38 Signaling Pathways in the Production of Humoral Erythropoiesis Regulators under Normal Conditions.

A M Dygai V V Zhdanov L A Miroshnichenko E V Udut G N Zyuz'kov T Yu Khrichkova E V Simanina E Yu Sherstoboev L A Stavrova A V Chaikovskii Ya V Burmina V I Agafonov D V Reikhart

Bull Exp Biol Med

E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine, Tomsk, Russia.

Published: November 2015

PI3- and MAP-kinase signaling pathways duplicate and interchange each other in production of agents that determine total erythropoietic activity under conditions of balanced erythropoiesis. The alternative p38-dependent MAP-kinase pathway is the major regulator of erythropoietic activity of adherent bone marrow cells. Blockade of PI3K and p38 signaling pathways stimulated production of erythropoietin by cells that do not produce it constitutively.

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http://dx.doi.org/10.1007/s10517-015-3087-2DOI Listing

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