AI Article Synopsis
- Researchers isolated isoketochabrolic acid (IKCA) from the brown algae Sargassum micracanthum found in Jeju Island, Korea, during a screening program for natural compounds.
- IKCA showed a strong inhibition of nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages, with an IC50 value of 58.31 μM, along with a reduction in various inflammatory cytokines.
- This study is the first to report the anti-inflammatory properties of IKCA, suggesting its potential use as an anti-inflammatory health supplement or in functional cosmetics.
Article Abstract
During our on-going screening program designed to isolate natural compounds from marine environments, we isolated isoketochabrolic acid (IKCA) from Sargassum micracanthum, an important brown algae distributed in Jeju Island, Korea. Furthermore, we evaluated the inhibitory effects of IKCA on nitric oxide (NO) production in lipopolysaccharide (LPS)-triggered macrophages. IKCA strongly inhibited NO production, with an IC50 value of 58.31 μM. Subsequent studies demonstrated that IKCA potently and concentration-dependently reduced prostaglandin E2 (PGE2), tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β, and IL-6 cytokine production. In conclusion, to the best of our knowledge, this is the first study to show that IKCA isolated from S. micracanthum has a potent anti-inflammatory activity. Therefore, IKCA might be useful as an anti-inflammatory health supplement or functional cosmetics.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4650962 | PMC |
| http://dx.doi.org/10.17179/excli2015-555 | DOI Listing |
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