Many countries struggle to develop and implement strategies to monitor hospitals nationally. The challenge is particularly acute in low-income countries where resources for measurement and reporting are scarce. We examined the experience of developing and implementing a national system for monitoring the performance of 130 government hospitals in Ethiopia. Using participatory observation, we found that the monitoring system resulted in more consistent hospital reporting of performance data to regional health bureaus and the federal government, increased transparency about hospital performance and the development of multiple quality-improvement projects. The development and implementation of the system, which required technical and political investment and support, would not have been possible without strong hospital-level management capacity. Thorough assessment of the health sector's readiness to change and desire to prioritize hospital quality can be helpful in the early stages of design and implementation. This assessment may include interviews with key informants, collection of data about health facilities and human resources and discussion with academic partners. Aligning partners and donors with the government's vision for quality improvement can enhance acceptability and political support. Such alignment can enable resources to be focused strategically towards one national effort - rather than be diluted across dozens of potentially competing projects. Initial stages benefit from having modest goals and the flexibility for continuous modification and improvement, through active engagement with all stakeholders.
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http://dx.doi.org/10.2471/BLT.14.151399 | DOI Listing |
J Biophotonics
March 2025
School of Mechanical Engineering, Kookmin University, Seoul, Republic of Korea.
This study evaluated the optomechanical and structural properties of individual macroscopic layers in swine skin tissues treated with a nontoxic optical clearing agent. The clearing agent was prepared by dissolving 2,2'-thiodiethanol in a phosphate-buffered solution and applied for up to 6 days. Prolonged clearing increased both the total and unscattered transmittance.
View Article and Find Full Text PDFFASEB J
March 2025
Department of Gerontology and Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Neuron-derived clone 77 (Nur77), a member of the orphan nuclear receptor family, is expressed and activated rapidly in response to diverse physiological and pathological stimuli. It exerts complex biological functions, including roles in the nervous system, genome integrity, cell differentiation, homeostasis, oxidative stress, autophagy, aging, and infection. Recent studies suggest that Nur77 agonists alleviate symptoms of neurodegenerative diseases, highlighting its potential as a therapeutic target in such conditions.
View Article and Find Full Text PDFFASEB J
March 2025
Department of Pharmaceutical Sciences, University of Connecticut, Storrs, Connecticut, USA.
Butyrophilin 3A1 (BTN3A1) is an integral membrane protein capable of detecting phosphoantigens, like (E)-4-hydroxy-3-methyl-but-2-enyl diphosphate (HMBPP), through its internal B30.2 domain. Detection of phosphoantigens leads to interactions with butyrophilin 2A1 and the subsequent activation of γδ-T cells.
View Article and Find Full Text PDFMetab Syndr Relat Disord
March 2025
Center for Nutrition and Health Research, National Institute of Public Health, Cuernavaca, México.
Metabolic syndrome (MetS) is a clinical construct that conglomerates risk factors interconnected with cardiovascular diseases and type 2 diabetes. More than a thousand million individuals in the world were diagnosed with MetS in 2018. Our objective was to examine the prevalence of MetS and its components among Mexican adults.
View Article and Find Full Text PDFAdv Sci (Weinh)
March 2025
Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, 710049, P. R. China.
Since its discovery in 1997, the single molecule surface-enhanced Raman spectroscopy (SM-SERS) has attracted wide interest owing to its enormous potential in many fields. However, the commercialized applications of SM-SERS are still limited by the lack of a clear understanding of the relevant mechanism in the famous SM-SERS experiments. In this study, a salt-gradient model is proposed to deeply investigate the physical nature and update insights into the morphological, structural, and component evolution processes of Ag NPs from dispersed nanostructures to aggregation states in the salt-induced aggregation SERS strategy.
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