A study of comparative antianginal efficiency of metoprolol (betaloc) and propranolol (anaprilin) in 30 patients with angina of effort, receiving single doses and courses of the treatment, demonstrated similar efficiency of the two drugs in 63.3% of the patients. In 30%, antianginal effect of metoprolol was superior to that of propranolol. Prognosis of treatment efficiency on the basis of an acute pharmacologic test was possible in 93.3% of cases with metoprolol, and in 83.3% with propranolol. The results of the acute pharmacological test help to substantiate its dose and schedule of administration.
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BMC Complement Med Ther
October 2024
Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.
Background: This study aims to investigate the short-term effects and safety of adjunct Suxiao Jiuxin Pills (SJPs) on conventional therapy in chronic coronary syndrome (CCS) patients who are intolerant to the adverse effects of long-acting nitrates.
Methods: This was a multicenter, randomized, double-blind, placebo-controlled trial. A total of 174 CCS participants from eight clinical study centers in China were included in the modified intention-to-treat analyses.
Molecules
August 2022
The Azrieli Faculty of Medicine, Bar-Ilan University, Safed 1311502, Israel.
Arginases are often overexpressed in human diseases, and they are an important target for developing anti-aging and antineoplastic drugs. Arginase type 1 (ARG1) is a cytosolic enzyme, and arginase type 2 (ARG2) is a mitochondrial one. In this study, a dataset containing 2115-FDA-approved drug molecules is virtually screened for potential arginase binding using molecular docking against several ARG1 and ARG2 structures.
View Article and Find Full Text PDFSignal Transduct Target Ther
September 2021
Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing, China.
Am J Med
December 2019
Johns Hopkins University, Towson, Md.
Background: Ranolazine is an anti-angina agent with many metabolites creating the potential for off-target effects. The U.S.
View Article and Find Full Text PDFInt J Cardiol
May 2019
Centro Cardiologico Universitario, University Hospital of Ferrara, Via Aldo Moro 8, 44124 Cona, Ferrara, Italy; Maria Cecilia Hospital, GVM Care & Research, Via Corriera 1, Cotignola, RA, Italy.
Background: The cornerstone of the treatment of patients affected by stable angina is based on drugs administration classified as first (beta-blockers, calcium channel blockers, short acting nitrates) or second line treatment (long-acting nitrates, ivabradine, nicorandil, ranolazine and trimetazidine). However, few data on comparison between different classes of drugs justify that one class of drugs is superior to another.
Methods: We performed a systematic review of the literature following PRISMA guidelines.
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