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Sexual and reproductive health is an essential part of comprehensive medical care. As the field of medicine becomes more specialized and siloed and the diagnostic work-up in surgery more advanced, the risk of anchoring diagnoses and partitioning of care increases. Thus, the fundamentals of a complete patient history and review of each body system remain critical in ensuring that surgeons establish a broad differential diagnosis; provide comprehensive, well-rounded care to patients; and create opportunities for patient counseling and interventions.
View Article and Find Full Text PDFThis study intends to optimize the carbon footprint management model of power enterprises through artificial intelligence (AI) technology to help the scientific formulation of carbon emission reduction strategies. Firstly, a carbon footprint calculation model based on big data and AI is established, and then machine learning algorithm is used to deeply mine the carbon emission data of power enterprises to identify the main influencing factors and emission reduction opportunities. Finally, the driver-state-response (DSR) model is used to evaluate the carbon audit of the power industry and comprehensively analyze the effect of carbon emission reduction.
View Article and Find Full Text PDFPrognostic immune markers in esophageal cancer patients managed with trimodal therapy.
Cancer Immunol Immunother
January 2025
Departments of Radiation Medicine, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, NY, 14263, USA.
Background: Esophageal cancer (ESC) is an aggressive disease which often presents at an advanced stage. Despite trimodal therapy, 40-50% patients can develop metastatic disease by 18 months. Identification of patients at risk for metastatic spread is challenging with need for improved prognostication.
View Article and Find Full Text PDFBasic Science and Pathogenesis.
Alzheimers Dement
December 2024
Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.
Background: In this introductory talk, we embark on a journey of through the genomic frontiers of Alzheimer's research via the revolutionary Alzheimer's Disease Sequencing Project (ADSP).
Method: ADSP integrates together various components that collectively unravel the intricate genetic landscape of Alzheimer's disease with the ultimate goal of advancing precision medicine for the millions affected globally by this devastating disease. With a goal of sequencing and analyzing up to 150,000 complete genomes and associated clinical and functional data in the next five years, ADSP has amassed an unprecedented wealth of genomic data from diverse populations, providing a comprehensive and holistic understanding of the genetic underpinnings of Alzheimer's disease.
Basic Science and Pathogenesis.
Alzheimers Dement
December 2024
Retromer Therapeutics, New York, NY, USA.
Genetic, cell biology and autopsied brain tissue studies indicate that deficits in the SORL1-retromer complex play a critical role in the pathogenesis of Alzheimer's disease (AD). SORL1 is an endosomal receptor that interacts with the retromer heterotrimer core complex consisting of VPS26-VPS35-VPS29. Together, SORL1-retromer regulate endosomal recycling of several AD-related cargos such as amyloid precursor protein.
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