AI Article Synopsis
- Toxin-antitoxin (TA) modules are essential for regulating bacterial and archaean metabolism and survival.
- Recent findings reveal that type II TA systems, traditionally thought to consist of two small proteins, may involve more complex, diverse toxins capable of forming multi-domain proteins.
- This review discusses a newly identified type II TA system where the toxin and antitoxin are combined into a single polypeptide, highlighting current research and suggesting directions for future investigation.
Article Abstract
Toxin-antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recently, we published a novel type II TA system in which toxin and antitoxin are covalently linked into a single polypeptide chain. In this review we summarize the current knowledge on these elongated toxin homologs and provide perspectives for future study.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826407 | PMC |
| http://dx.doi.org/10.1007/s00294-015-0541-7 | DOI Listing |
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