The growth-inhibitory properties of a 5-nitrothiazole series were evaluated against Trypanosoma brucei. A subset of related compounds displayed the greatest potency toward the parasite while exhibiting little cytotoxic effect on mammalian cells, with this antiparasitic activity dependent on expression of a type I nitroreductase by the trypanosome. We conclude that the 5-nitrothiazole class of nitroheterocyclic drugs may represent a new lead in the treatment of human African trypanosomiasis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750693 | PMC |
| http://dx.doi.org/10.1128/AAC.02006-15 | DOI Listing |
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