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Prevalence of difficult-to-treat resistance in ESKAPE pathogens in a third level hospital in Mexico.

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Department of Infectious Diseases, Hospital Universitario "Dr. José E. González" y Facultad de Medicina, Universidad Autónoma de Nuevo León, Mitras Centro, Monterrey, Nuevo León, CP 64460, México.

Background: Antimicrobial resistance and difficult-to-treat resistance (DTR) in ESKAPE pathogens ( and species) is a threat to human health. The aim of this study was to determine the prevalence of antimicrobial resistance and DTR rates in ESKAPE pathogens over six years in a third-level hospital from Monterrey, Mexico.

Methods: Antimicrobial susceptibility testing was determined by either disk diffusion or broth microdilution in strains from 2018 to 2023.

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In the field of cattle medicine in Austria, to date, few studies have investigated the presence of methicillin-resistant and extended-spectrum β-lactamase-producing in Austria. For this reason, milk and nasal samples were examined for the presence of methicillin-resistant as well as fecal samples for extended-spectrum cephalosporin-resistant . The nasal and fecal swabs were collected during the veterinary treatment of calf pneumonia and calf diarrhea.

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Background: Antimicrobial resistance (AMR) in livestock and the environment likely contribute to the prevalence of AMR in humans with potential detrimental effects on human health. As such, annual mandatory monitoring of AMR in livestock occurs within the European Union (EU), according to harmonised methods. Extended-spectrum cephalosporins-resistant (ESC-resistant) , including extended-spectrum β-lactamases (ESBL), AmpC β-lactamases (AmpC) and carbapenemase producing , are considered of particular importance and are therefore included in the monitoring program.

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Article Synopsis
  • Antimicrobial resistance (AMR) in Enterobacterales, particularly in Escherichia coli, poses serious health and economic issues for humans and animals, highlighting the "One Health" approach to understanding this problem.
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Objective: Aim to investigate the pathogens distribution and drug resistance of gram-negative bacteria causing bloodstream infection (BSIs) in Infectious Disease Surveillance of Pediatric from 2016 to 2022. The prevalence of four important drug resistance phenotypes was studied: difficult-to-treat resistance, fluoroquinolone resistance, carbapenem resistance, and extended-spectrum cephalosporin resistance, and to provide reference basis for preventing and treating BSIs diseases in children.

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