In 2015, Federal Service on surveillance in consumers rights protection and public well-being set a task to organize planned work of regional agencies on basis of risk-oriented model of control and supervision. Based on results of pilot project in Rospotrebnadzor Department of Perm area and St-Petersburg, the article covers methodic approaches to classification of objects liable to surveillance in occupational hygiene. The classification considers possibility of sanitary law violation, severity of this violation consequences and number of workers exposed to risk factors including hazardous work conditions. The authors specified recommendations on periodicity and forms of planned inspections considering evaluation of potential risk for human health, determined problems that require solution in implementation of risk-oriented model of surveillance.
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Environ Sci Technol
June 2024
China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China.
Anthropogenic emissions, originating from human activities, stand as the primary contributors to PM, which is recognized as a global health threat. The disease burden associated with PM has been extensively documented. However, the prevailing estimations have predominantly relied on PM exposure-response functions, neglecting the distinct risks posed by PM from various sources.
View Article and Find Full Text PDFHeliyon
April 2024
Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Background: Globally, lung carcinoma remains the leading cause of death, with its associated morbidity and mortality rates remaining elevated. Despite the slow advancement of treatment, the outlook remains bleak. Cellular senescence represents a halt in the cell cycle, encompassing a range of physiological and pathological activities, along with diverse phenotypic alterations, including variations in secretory phenotype, macromolecular harm, and metabolic disturbances.
View Article and Find Full Text PDFFront Oncol
January 2024
Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Dr. Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico.
Background: Advances in the understanding of the pathobiology of childhood B-cell acute lymphoblastic leukemia (B-ALL) have led towards risk-oriented treatment regimens and markedly improved survival rates. However, treatment-related toxicities remain a major cause of mortality in developing countries. One of the most common adverse effects of chemotherapy in B-ALL is the hematologic toxicity, which may be related to genetic variants in membrane transporters that are critical for drug absorption, distribution, and elimination.
View Article and Find Full Text PDFHeliyon
September 2023
College of Economics & Management, Shandong Agricultural University, China.
This study examines the impact of farmers' risk perceptions on their decision to transfer-out farmland, as well as the variations in this influence based on different risk preferences. The research utilizes survey data from 1389 farmers in rural China. By expanding the decision-making model for farmer households within the context of risk perception, this paper analyzes the equilibrium point of farmers' decision-making using mathematical models.
View Article and Find Full Text PDFAnn Vasc Dis
March 2023
Department of General Internal Medicine and Emergency Medicine, Fujita Medical University School of Medicine, Toyoake, Aichi, Japan.
To assess the external validity of the Padua and International Medical Prevention Registry on Venous Thromboembolism (IMPROVE-VTE) risk assessment models (RAMs) for predicting venous thromboembolism (VTE) within 90 days of admission among hospitalized medical patients in Japan. A university hospital cohort comprising 3876 consecutive patients ages ≥15 years admitted to a general internal medicine department between July 2016 and July 2021 was retrospectively analyzed using data extracted from their medical records. A total of 74 VTE events (1.
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