The objective of this article is to explore the impact of socioeconomic status on outcome metrics in post-burn injury patients. Retrospective review of patients with TBSA >15% between 2005 and 2012. Demographics and clinical course were recorded. Socioeconomics were approximated using census data of percent below poverty level at patient zip code, which was also used for calculating distance to regional burn center. Statistical analysis was performed using Statistical Analysis Software. Odds ratios and 95% confidence intervals were calculated followed by regression models for factors associated with graft loss and readmission. Two hundred and fifty subjects survived to discharge: 33% were of upper socioeconomic status, 32% were of middle status, and 35% were of lower status. Fourteen percentage of patients lived <99 miles from the burn center, 60% 100 to 249 miles away, and 26% >240 miles away. Eighty readmissions occurred among 39 patients; 43% were unplanned. Each percent increase in TBSA was associated with a 5% increase in likelihood of being readmitted. Thirty six percentage of readmission patients were covered under worker's compensation. Patients with worker's compensation were four times more likely to be readmitted than private insurance. Only worker's compensation had a majority of unplanned readmissions (58%). Graft loss occurred in 12% of patients. Those in the low socioeconomic group had five times the odds of having graft loss than those in the high socioeconomics. There was no correlation between graft loss and insurance status or distance. Findings indicate strong and statistically significant correlations between type of insurance and likelihood of readmission and between graft loss and poverty.
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Front Biosci (Landmark Ed)
January 2025
Department of Otolaryngology, Head and Neck Surgery, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, 330006 Nanchang, Jiangxi, China.
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Artif Organs
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View Article and Find Full Text PDFPharmaceutics
January 2025
Department of General and Transplant Surgery, Poznan University of Medical Sciences, 60-355 Poznan, Poland.
: Chronic antibody-mediated rejection (cAMR) constitutes a serious challenge in the long-term success of organ transplantation. It is associated with donor-specific antibodies (DSAs) which activate a complement pathway in response to the presence of human leukocyte antigens (HLAs) on the graft, which results in chronic inflammation and leads to graft dysfunction. One of the recent promising methods of cAMR treatment is a recombinant humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody referred to as Tocilizumab (TCZ).
View Article and Find Full Text PDFInt J Mol Sci
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The World Health Organization estimates that approximately 285 million people suffer from visual impairments, around 5% of which are caused by corneal pathologies. Currently, the most common clinical treatment consists of a corneal transplant (keratoplasty) from a human donor. However, worldwide demand for donor corneas amply exceeds the available supply.
View Article and Find Full Text PDFInt J Mol Sci
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Immunology Department, University Hospital Marqués de Valdecilla, 39008 Santander, Spain.
The human leukocyte antigen (HLA) system plays a critical role in transplant immunology, influencing outcomes through various immune-mediated rejection mechanisms. Hyperacute rejection is driven by preformed donor-specific antibodies (DSAs) targeting HLAs, leading to complement activation and graft loss within hours to days. Acute rejection typically occurs within six months post-transplantation, involving cellular and humoral responses, including the formation of de novo DSAs.
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