Background: First described in 1872, syringomas are common intraepidermal sweat gland tumors most often found in women during adolescence. Frequent involvement areas are the lower eyelids and malar areas; vulvar involvement is relatively rare. These lesions often appear as small, separate, yellowish papules of about 1-3 mm in size and are generally associated with increased vulvar discomfort and itching.They typically occur in multiples and are bilateral and symmetrical.
Case: A 52-year-old, postmenopausal woman presented with vulvar pruritis and was diagnosed with syringomas after vulvar biopsy in our polyclinics.
Conclusion: Vulvar syringoma should be included in the differential diagnosisf or itchy and papular lesions of vulvae in a postmenopausal woman.
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Cochrane Database Syst Rev
January 2025
Department of Medicine, Faculty of Medicine, University of Ottawa, Ottawa, Canada.
Rationale: Osteoporosis is an abnormal reduction in bone mass and bone deterioration, leading to increased fracture risk. Alendronate belongs to the bisphosphonate class of drugs, which inhibit bone resorption by interfering with the activity of osteoclasts (bone cells that break down bone tissue). This is an update of a Cochrane review first published in 2008.
View Article and Find Full Text PDFPak J Med Sci
January 2025
Almila Senat, Department of Biochemistry, Republic of Turkey Ministry of Health, Taksim Training and Research Hospital, Istanbul, Turkey.
Objective: This study aimed to investigate the relationship between oxidative stress (OS) and endometrial polyps (EP) in pre- versus postmenopausal women with abnormal uterine bleeding.
Methods: This prospective case control study was conducted in the Gynecology Department of Ankara Bilkent City Hospital between January and December 2019. In this study, the EP and control groups included 45 participants each (30 pre- and 15 postmenopausal women).
Clonal hematopoiesis of indeterminate potential (CHIP) is associated with increased mortality and malignancy risk, yet the determinants of clonal expansion remain poorly understood. We performed sequencing at >4,000x depth of coverage for CHIP mutations in 6,986 postmenopausal women from the Women's Health Initiative at two timepoints approximately 15 years apart. Among 3,685 mutations detected at baseline (VAF ≥ 0.
View Article and Find Full Text PDFCureus
December 2024
Gynecology, Unidade Local de Saúde de Coimbra, Coimbra, PRT.
Introduction: Transvaginal retropubic (TVT-R) and transobturator (TVT-O) midurethral slings are the main surgical options for stress urinary incontinence (SUI). Surgical indications for each of them are defined by clinical and history presentation. These techniques play a particular role in SUI recurrence after a previous urinary incontinence surgery, although there are few studies comparing their efficacy.
View Article and Find Full Text PDFInt J Womens Health
January 2025
Department of Endocrinology, The First People's Hospital of Xiaoshan District, Hangzhou, Zhejiang, People's Republic of China.
Background: Osteoporosis is a common health concern in postmenopausal women. Obesity, commonly assessed using body mass index (BMI), may have a protective effect on osteoporosis in postmenopausal women. As BMI is limited to the distinguishing fat accumulation, the study aimed to explore the association between allometric body shape indices [including a body shape index (ABSI), hip index, (HI), and waist-hip index (WHI)] and osteoporosis in postmenopausal women.
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