The rate of caesarean section (CS) at Muhimbili National Hospital (MNH) in Tanzania has been on progressive increase for past three decades. Concerns have been raised if this increase is justified by rational decisions but no study so far has investigated this problem. The aim of the study was to find out whether decisions made for CS comply with a set of locally made standards, with an assumption that if the standards are met, then the increase in CS rate seen at MNH is genuine. The five most common indications for CS were identified from the obstetric electronic data base. Most common indications included obstructed labour, cephalopelvic disproportion (CPD), failure to progress, repeat CS and foetal distress. Criteria for the best practice for each indication were developed based on the National guidelines and local expert consensus. Information extracted from the case notes, antenatal cards and partographs were compared to the standard audit criteria and the decision judged as standard or substandard. Three hundred forty five women had a decision made for emergency CS. Repeat CS was the most frequent indication (30.2%), followed by obstructed labour (14.4%) and foetal distress (13.6%). Audit of 324 women's files showed that 30% of women had substandard decisions for CS mostly in the foetal distress group (59.1%) and least in the repeat CS group (9.1%). Among the-324 mothers with decision for emergency CS, 279 (86.1%) delivered by CS as decided and 45 (13.9%) delivered vaginally before CS could be performed. Women who delivered vaginally after decision for CS and the nulliparous women had significantly more substandard decisions compared to those delivered by CS and parous women respectively. In conclusion, a substantial proportion of decisions for emergency CS made in the hospital is substandard and may contain women in whom surgical intervention could be avoided. This calls for a need to improve quality of assessment and decision before performing CS.
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Cureus
December 2024
Department of Psycho-Neuroscience and Recovery, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, ROU.
This study investigated the relationship between maternal serum amyloid A (SAA) levels, a biomarker of systemic inflammation, and specific neonatal outcomes in preterm birth (PTB). The study included 66 consecutive pregnant women hospitalized for spontaneous preterm delivery (ranging from 28 to 36 gestational weeks), at the Timisoara Municipal Hospital. The study measured mSAA levels to assess their potential as predictors of fetal outcomes (respiratory distress syndrome [RDS]), as well as their association with APGAR score, neonatal leukocyte count, and C-reactive protein (CRP) levels as indicators of neonatal status and response.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
National Medical Research Center for Obstetrics, Gynecology and Perinatology Named After Academician Kulakov V.I., 117997 Moscow, Russia.
Despite the increasing number of placenta accreta spectrum (PAS) cases in recent years, its impact on neonatal outcomes and respiratory morbidity, as well as the underlying pathogenetic mechanism, has not yet been extensively studied. Moreover, no study has yet demonstrated the effectiveness of antenatal corticosteroid therapy (CT) for the prevention of respiratory distress syndrome (RDS) in newborns of mothers with PAS at the molecular level. In this regard, microRNA (miRNA) profiling by small RNA deep sequencing and quantitative real-time PCR was performed on 160 blood plasma samples from preterm infants (gestational age: 33-36 weeks) and their mothers who had been diagnosed with or without PAS depending on the timing of the antenatal RDS prophylaxis.
View Article and Find Full Text PDFBest Pract Res Clin Anaesthesiol
September 2024
Department of Anaesthesiology, University Hospitals Leuven (BE), Department of Cardiovascular Sciences, KU Leuven (BE), Herestraat 49, B-3000, Leuven, Belgium.
Critical illness during pregnancy poses significant challenges driven by complex interactions between physiological changes, pre-existing conditions, and healthcare disparities. In high-income countries, increasing maternal age and comorbidities complicate obstetric care by triggering an unprecedented rise in cardiac disease during pregnancy, while infections like influenza and COVID-19 are important causes of maternal adult respiratory distress syndrome. Extracorporeal membrane oxygenation (ECMO) gained prominence as a vital intervention, providing respiratory and/or cardiac support, for varying indications between antenatal and postpartum periods.
View Article and Find Full Text PDFFront Glob Womens Health
December 2024
College of Medicine and Health Sciences, Bahirdar University, Bahirdar, Ethiopia.
Background: Meconium is thick black-green fetal intestinal content starting from the early first trimester of gestation. Unfortunately, if it is released into the amniotic cavity due to any cause, it can be associated with neonatal mortality and morbidity.
Objective: To identify the factors associated with meconium-stained amniotic fluid among mothers undergoing emergency cesarean section in specialized hospitals cross-sectional study in south central Ethiopia from August 1, 2022, to 30, October 2022.
Cureus
December 2024
Obstetrics, Orlando Regional Medical Center, Orlando, USA.
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