This paper presents the analysis of relationships between geometrical parameters of the tubular leaflet apparatus and its functional characteristics. In addition, the degree of the influence of deformation of different zones of leaflets on its ability to perform its function is evaluated in this work. The outcomes of this study could be helpful in developing new models of the transcatheter prosthetic heart valves leaflet apparatus or analyzing existing in-clinical transcatheter aortic valve implantation prostheses.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Numerical simulation of fluid-structure interaction analysis for the performance of leaflet reimplantation with different types of artificial graft.
Comput Methods Programs Biomed
January 2025
College of Chemistry and Life Science, Beijing University of Technology, Beijing 100124, China; Beijing International Science and Technology Cooperation Base for Intelligent Physiological Measurement and Clinical Transformation, Beijing 100124, China. Electronic address:
Background And Objective: In clinical practice, valve-sparing aortic root replacement surgery primarily addresses left ventricular dysfunction in patients due to severe aortic regurgitation, but there is controversy regarding the choice of surgical technique. In order to investigate which type of valve-sparing aortic root replacement surgeries can achieve better blood flow conditions, this study examines the impact of changes in the geometric morphology of the aortic root on the hemodynamic environment through numerical simulation.
Methods: An idealized model of the aortic root was established based on data obtained from clinical measurements, including using the model of the aortic root without significant lesions as the control group (Model C), while using surgical models of leaflet reimplantation with tubular graft (Model T), leaflet reimplantation with Valsalva graft (Model V), and the Florida sleeve procedure (Model F) as the experimental groups.
Fluid-Solid Interaction Analysis for Developing In-Situ Strain and Flow Sensors for Prosthetic Valve Monitoring.
Sensors (Basel)
August 2024
Department of Engineering, University of Palermo, 90128 Palermo, Italy.
Transcatheter aortic valve implantation (TAVI) was initially developed for adult patients, but there is a growing interest to expand this procedure to younger individuals with longer life expectancies. However, the gradual degradation of biological valve leaflets in transcatheter heart valves (THV) presents significant challenges for this extension. This study aimed to establish a multiphysics computational framework to analyze structural and flow measurements of TAVI and evaluate the integration of optical fiber and photoplethysmography (PPG) sensors for monitoring valve function.
View Article and Find Full Text PDFPredicting lipid sorting in curved membranes.
Methods Enzymol
July 2024
Molecular Microbiology and Structural Biochemistry, UMR 5086 CNRS & University of Lyon, Lyon, France; Institut National de la Santé et de la Recherche Médicale, Lyon, France. Electronic address:
Most biological membranes are curved, and both lipids and proteins play a role in generating curvature. For any given membrane shape and composition, it is not trivial to determine whether lipids are laterally distributed in a homogeneous or inhomogeneous way, and whether the inter-leaflet distribution is symmetric or not. Here we present a simple computational tool that allows to predict the preference of any lipid type for membranes with positive vs.
View Article and Find Full Text PDFDifferential effects of ganglioside lipids on the conformation and aggregation of islet amyloid polypeptide.
Protein Sci
August 2024
Biophysics Program, University of Michigan, Ann Arbor, Michigan, USA.
Despite causing over 1 million deaths annually, Type 2 Diabetes (T2D) currently has no curative treatments. Aggregation of the islet amyloid polypeptide (hIAPP) into amyloid plaques plays an important role in the pathophysiology of T2D and thus presents a target for therapeutic intervention. The mechanism by which hIAPP aggregates contribute to the development of T2D is unclear, but it is proposed to involve disruption of cellular membranes.
View Article and Find Full Text PDF, a new species of (Fabaceae) from Xinjiang, China.
PhytoKeys
June 2024
Yili Normal University/Xinjiang Key Laboratory of Lavender Conservation and Utilization, Xinjiang 830500, Yining, China Yili Normal University Yining China.
A new species, Z. Z. Yang & Q.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!