We present the case of a 37-year-old man who was diagnosed with an Epstein-Barr futile myocarditis. The diagnosis was made in the Accident and Emergency Department, with the input of portable echocardiography. The patient subsequently underwent an urgent orthotopic heart transplantation and he has now completely recovered.
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http://dx.doi.org/10.1177/0267659115618460 | DOI Listing |
Perfusion
July 2016
Cardiology Department, Kingston Hospital, London, UK Cardiology Department, Papworth Hospital, Cambridge, UK
We present the case of a 37-year-old man who was diagnosed with an Epstein-Barr futile myocarditis. The diagnosis was made in the Accident and Emergency Department, with the input of portable echocardiography. The patient subsequently underwent an urgent orthotopic heart transplantation and he has now completely recovered.
View Article and Find Full Text PDFBlood
November 2014
Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA;
Corticosteroids are the accepted primary therapy for acute graft-versus-host disease (GVHD), but durable responses are seen in only about half of the patients. Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0802, a phase 3 multicenter randomized double-blinded trial, was designed to test whether mycophenolate mofetil (MMF) plus corticosteroids was superior to corticosteroids alone as initial therapy for acute GVHD. Patients with newly diagnosed acute GVHD were eligible if they required systemic therapy.
View Article and Find Full Text PDFEur Heart J
April 2011
Klinik für Innere Medizin III, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Kirrberger Strasse 1, Homburg/Saar, Germany.
Aims: Serological analyses of viral infection in suspected myocarditis are still widely used, although convincing evidence for their value is lacking. We determined prospectively the diagnostic value of virus serology in comparison with endomyocardial biopsy (EMB) including viral genome detection and immunohistochemistry in patients with clinically suspected myocarditis.
Methods And Results: Virus serology and state-of-the-art evaluation of EMB were performed in 124 patients (age 40 ± 15 years) with suspected myocarditis.
Pathobiology
January 2007
Institute of Pathology, Medical University of Innsbruck, Innsbruck, Austria.
The World Health Organization has acknowledged the malignant nature of classical Hodgkin lymphoma (cHL), which encompasses four histological subtypes. The diagnosis of cHL is based on the detection of malignant Hodgkin and Reed-Sternberg cells (HRSC) confirmed by immunophenotyping and the detection of growth patterns specific to each histological subtype. The pathologic HRSC arise from germinal center or immediate postgerminal cells that lack detectable immunoglobulin/B-cell antigen receptor expression, with a consequent loss of B-cell identity; very few cHL cases are of T-cell origin.
View Article and Find Full Text PDFJ Med Chem
January 1998
Department of Chemistry, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201-1379, USA.
New nucleoside analogues 14-17 based on a methylenecyclopropane structure were synthesized and evaluated for antiviral activity. Reaction of 2,3-dibromopropene (19) with adenine (18) led to bromoalkene 20, which was benzoylated to give N6,N6-dibenzoyl derivative 23. Attempts to convert 20 or 23 to bromocyclopropanes 21 and 22 by reaction with ethyl diazoacetate catalyzed by Rh2(OAc)4 were futile.
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