Imaging autofluorescence temporal signatures of the human ocular fundus in vivo.

J Biomed Opt

University of California, Los Angeles, Department of Bioengineering, 410 Westwood Plaza, Room 5121, Engineering V, P.O. Box 951600, Los Angeles, California 90095-1600, United States.

Published: November 2015

AI Article Synopsis

  • The study showcases a new technology for real-time imaging of the eye's fundus using fluorescence lifetime imaging for the first time.
  • This method utilizes light-emitting diodes to create detailed images that highlight tissue differences without needing complex calculations.
  • Initial results indicate its potential for early detection of macular diseases by analyzing specific fluorescence markers in the retina.

Article Abstract

We demonstrate real-time in vivo fundus imaging capabilities of our fluorescence lifetime imaging technology for the first time. This implementation of lifetime imaging uses light emitting diodes to capture full-field images capable of showing direct tissue contrast without executing curve fitting or lifetime calculations. Preliminary results of fundus images are presented, investigating autofluorescence imaging potential of various retina biomarkers for early detection of macular diseases.

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http://dx.doi.org/10.1117/1.JBO.20.11.110505DOI Listing

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