Is T1ρ Mapping an Alternative to Delayed Gadolinium-enhanced MR Imaging of Cartilage in the Assessment of Sulphated Glycosaminoglycan Content in Human Osteoarthritic Knees? An in Vivo Validation Study.

Radiology

From the Departments of Radiology (J.v.T., G.K., E.E.B., S.K., G.P.K., E.H.G.O.), Orthopedic Surgery (J.v.T., M.R., P.K.B., G.J.V.M.v.O., J.A.N.V.), Medical Informatics (E.E.B., S.K.), Biostatistics (K.N.), and Otorhinolaryngology (G.J.V.M.v.O.), Erasmus University Medical Center, PO Box 2040, 3000 CA Rotterdam, the Netherlands; Department of Biomechanical Engineering, Delft University of Technology, Delft, the Netherlands (H.W.); and Department of Orthopedics and Rheumatology, University Medical Center Utrecht, Utrecht, the Netherlands (H.W.).

Published: May 2016

AI Article Synopsis

  • This study aimed to see if T1ρ mapping can replace the delayed gadolinium-enhanced magnetic resonance imaging (dGEMRIC) method for measuring cartilage composition in osteoarthritis patients.
  • Twelve patients with knee osteoarthritis underwent both dGEMRIC and T1ρ mapping before knee replacement surgery, with cartilage samples analyzed for biochemical content using specific assays.
  • Results indicated that dGEMRIC strongly correlates with cartilage sGAG content but T1ρ mapping showed no correlation, suggesting that dGEMRIC is a reliable method for assessing cartilage health in this condition.

Article Abstract

Purpose: To determine if T1ρ mapping can be used as an alternative to delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the quantification of cartilage biochemical composition in vivo in human knees with osteoarthritis.

Materials And Methods: This study was approved by the institutional review board. Written informed consent was obtained from all participants. Twelve patients with knee osteoarthritis underwent dGEMRIC and T1ρ mapping at 3.0 T before undergoing total knee replacement. Outcomes of dGEMRIC and T1ρ mapping were calculated in six cartilage regions of interest. Femoral and tibial cartilages were harvested during total knee replacement. Cartilage sulphated glycosaminoglycan (sGAG) and collagen content were assessed with dimethylmethylene blue and hydroxyproline assays, respectively. A four-dimensional multivariate mixed-effects model was used to simultaneously assess the correlation between outcomes of dGEMRIC and T1ρ mapping and the sGAG and collagen content of the articular cartilage.

Results: T1 relaxation times at dGEMRIC showed strong correlation with cartilage sGAG content (r = 0.73; 95% credibility interval [CI] = 0.60, 0.83) and weak correlation with cartilage collagen content (r = 0.40; 95% CI: 0.18, 0.58). T1ρ relaxation times did not correlate with cartilage sGAG content (r = 0.04; 95% CI: -0.21, 0.28) or collagen content (r = -0.05; 95% CI = -0.31, 0.20).

Conclusion: dGEMRIC can help accurately measure cartilage sGAG content in vivo in patients with knee osteoarthritis, whereas T1ρ mapping does not appear suitable for this purpose. Although the technique is not completely sGAG specific and requires a contrast agent, dGEMRIC is a validated and robust method for quantifying cartilage sGAG content in human osteoarthritis subjects in clinical research.

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Source
http://dx.doi.org/10.1148/radiol.2015150693DOI Listing

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