Chimeric antigen receptor (CAR) T cells have enjoyed unprecedented clinical success against haematological malignancies in recent years. However, several aspects of CAR T cell biology remain unknown. We recently compared CAR and T cell receptor (TCR)-based killing in the same effector cell and showed that CAR T cells can not only efficiently kill single tumor targets, they can also kill multiple tumor targets in a sequential manner. Single and serial killing events were not sustained long term due to CAR down-regulation after 20 hours.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4635863 | PMC |
| http://dx.doi.org/10.1080/2162402X.2015.1053684 | DOI Listing |
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