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| http://dx.doi.org/10.11604/pamj.2015.21.307.7071 | DOI Listing |
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Olive oil and castor oil-based self-nanoemulsifying drug delivery system of flurbiprofen can relieve peripheral pain and inflammation through reduction of oxidative stress and inflammatory biomarkers: a comprehensive formulation and pharmacological insights.
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January 2025
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, 45210, Pakistan.
Flurbiprofen (FBP) is poorly water-soluble BCS class II drug with anti-inflammatory and analgesic effects, used to treat arthritis and degenerative joint diseases. This study was aimed to develop SNEDDS loaded with FBP. Six SNEDDS using two oils olive oil (F, F, F) and castor oil (F, F, F) with three different Smix ratios consisting of Tween 20 and PEG 400 (1:1, 1:2, 2:1) were prepared and characterized.
View Article and Find Full Text PDFPseudo-Sciatica Pain Due to a Biceps Femoris Muscle Tear.
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Intervention and Musculoskeletal Rehabilitation, Centro de Reabilitação do Norte, Unidade Local de Saúde (ULS) Gaia/Espinho, Vila Nova de Gaia, PRT.
Hamstring injuries (HSIs) are common among athletes, particularly in high-speed sports, and are frequently associated with prolonged recovery periods and a high recurrence rate. This study presents a 36-year-old male with sciatica-like symptoms following an acute hamstring tear during an amateur football match. The patient experienced this pain two weeks after the injury, suggesting potential sciatic nerve involvement.
View Article and Find Full Text PDFThermal Annuloplasty for the Treatment of Discogenic Low Back Pain With a High-Intensity Zone After Full Endoscopic Discectomy.
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Spinal Surgery, Kameda Medical Center, Chiba, JPN.
Article Synopsis
- Discogenic low back pain (DLBP) is challenging to diagnose, but full endoscopic spinal surgery with thermal annuloplasty has shown good results in treating refractory cases, as demonstrated in a report of a 22-year-old female patient.
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Network Pharmacology and In Vivo Experimental Verification of the Mechanism of the Qing'e Pill for Treating Intervertebral Disc Degeneration.
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Objective: The Qing'e Pill (QEP) is widely used to alleviate low back pain and sciatica caused by Intervertebral Disc Degeneration (IDD). However, its active components, key targets, and molecular mechanisms are not fully understood. The aim of this study is to elucidate the molecular mechanisms through which the QEP improves IDD using database mining techniques.
View Article and Find Full Text PDFSpontaneous multilevel lumbar pediculolysis associated with spondylolysis: a rare case and review of the literature.
BMC Musculoskelet Disord
November 2024
Department of Orthopedics, The Affliated Hospital of Southwest Medical University, Luzhou, Sichuan, 646000, PR China.
Background: Pediculolysis is bone hypertrophy and pseudoarthrosis caused by pedicle fracture and has often been combined with contralateral spondylolysis in previous reports. Multilevel pediculolysis with spondylolysis is extremely rare, and we report a case who underwent surgery. Cases of multisegment pediculolysis were reviewed to inspire the diagnosis and treatment of similar pathological phenomena.
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