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HIV pre-exposure prophylaxis and its implementation in the PrEP Impact Trial in England: a pragmatic health technology assessment.
Lancet HIV
December 2023
UK Health Security Agency, London, UK.
Article Synopsis
- - The Impact Trial evaluated the need and effectiveness of HIV pre-exposure prophylaxis (PrEP) among attendees of sexual health services (SHS) in England from 2017 to 2020, focusing on who could benefit from PrEP and how well it was utilized.
- - The study included over 21,350 participants, predominantly men who have sex with men (95.5%), with a significant uptake of PrEP at 57.1% among those identified as at risk.
- - Findings indicated that many participants engaged with the trial by attending follow-up visits, resulting in a median duration of PrEP use of about 361 days, highlighting its role in HIV prevention strategies.
Case of apparent mpox reinfection.
Sex Transm Infect
June 2023
Southwest Regional Laboratory, UK Health Security Agency, North Bristol NHS Trust, Bristol, UK.
We present an apparent second episode of mpox (monkeypox) genital ulcerative disease in a non-immunosuppressed MSM (man who has sex with men) patient who had completely recovered from a primary mpox infection 4 months previously. The patient had also received a complete two-dose course of smallpox vaccination between the two presentations. This case highlights the importance of continuing to include mpox in the differential diagnoses for individuals presenting with genital or mucosal ulceration, regardless of assumed immunity derived from prior infection or vaccination.
View Article and Find Full Text PDFUnintended consequences: the potential impacts of the British Association for Sexual Health and HIV (BASHH) 2019 gonorrhoea guidelines.
Int J STD AIDS
March 2021
Liverpool University Hospitals NHS Foundation Trust, Royal Liverpool University Hospital, Liverpool, UK.
In 2019 the British Association for Sexual Health and HIV (BASHH) guidelines for the management of gonorrhoea were updated. Epidemiological treatment was reserved for sexual contacts presenting within 14 days of exposure only. The aim of this evaluation was to review the potential implications of the new guidelines on the management of gonorrhoea contacts.
View Article and Find Full Text PDFEpididymitis and its aetiologies in a central London sexual health clinic.
Int J STD AIDS
January 2021
Sexual Health Department, Guy's & St. Thomas NHS Foundation Trust, London, UK.
Article Synopsis
- - The study reviewed cases of epididymitis from three sexual health clinics over a year, finding it is a common cause of scrotal pain, with 127 cases analyzed (average age 32 years).
- - Only 11% of the cases were linked to sexually transmitted infections (STIs), including chlamydia and gonorrhea, with more cases found in those under 35 years old.
- - Most patients were treated with antibiotics, but 91% did not follow up after two weeks, and 7% remained symptomatic post-treatment.
High prevalence of anti-hepatitis A IgG in a cohort of UK HIV-negative men who have sex with men: implications for local hepatitis A vaccine policy.
Int J STD AIDS
September 2018
1 County Durham and Darlington NHS Foundation Trust (CDDFT), Darlington, UK.
BASHH guidelines recommend that 'the hepatitis A virus total antibody test can be offered to at-risk patients whose immune status is unknown … depending on local funding arrangements'. We sought to measure the local prevalence of anti-hepatitis A (HAV) IgG in HIV-negative men who have sex with men (MSM), to inform the utility of pre-vaccination screening. We assessed the prevalence of anti-HAV IgG in HIV-negative MSM who attended sexual health services in County Durham and Darlington, UK, from March to August 2017.
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