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Calcium-mediated mitochondrial fission and mitophagy drive glycolysis to facilitate arterivirus proliferation.
PLoS Pathog
January 2025
Key Laboratory of Animal Diseases Diagnostic and Immunology, Ministry of Agriculture, MOE International Joint Collaborative Research Laboratory for Animal Health & Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China.
Mitochondria, recognized as the "powerhouse" of cells, play a vital role in generating cellular energy through dynamic processes such as fission and fusion. Viruses have evolved mechanisms to hijack mitochondrial function for their survival and proliferation. Here, we report that infection with the swine arterivirus porcine reproductive and respiratory syndrome virus (PRRSV), manipulates mitochondria calcium ions (Ca2+) to induce mitochondrial fission and mitophagy, thereby reprogramming cellular energy metabolism to facilitate its own replication.
View Article and Find Full Text PDFTranscriptional dynamics during Heliothis zea nudivirus 1 infection in an ovarian cell line from .
J Gen Virol
January 2025
Laboratory of Virology, Wageningen University and Research, 6708 PB Wageningen, Netherlands.
Nudiviruses (family ) are double-stranded DNA viruses that infect various insects and crustaceans. Among them, Heliothis zea nudivirus 1 (HzNV-1) represents the rare case of a lepidopteran nudivirus inducing a sexual pathology. Studies about molecular pathological dynamics of HzNV-1 or other nudiviruses are scarce.
View Article and Find Full Text PDFMicrocephaly protein ANKLE2 promotes Zika virus replication.
mBio
January 2025
Department of Microbiology and Molecular Genetics, University of California, Davis, California, USA.
Orthoflaviviruses are positive-sense single-stranded RNA viruses that hijack host proteins to promote their own replication. Zika virus (ZIKV) is infamous among orthoflaviviruses for its association with severe congenital birth defects, notably microcephaly. We previously mapped ZIKV-host protein interactions and identified the interaction between ZIKV non-structural protein 4A (NS4A) and host microcephaly protein ankyrin repeat and LEM domain-containing 2 (ANKLE2).
View Article and Find Full Text PDFMaize Herbivore-Induced Volatiles Enhance Xenobiotic Detoxification in Larvae of and .
Plants (Basel)
December 2024
Ministry of Education Key Laboratory for Genetics, Breeding and Multiple Utilization of Crop, Laboratory of Ministry of Agriculture and Rural Affairs of Biological Breeding for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China.
The release of herbivore-induced plant volatiles (HIPVs) has been recognized to be an important strategy for plant adaptation to herbivore attack. However, whether these induced volatiles are beneficial to insect herbivores, particularly insect larvae, is largely unknown. We used the two important highly polyphagous lepidopteran pests and to evaluate the benefit on xenobiotic detoxification of larval exposure to HIPVs released by the host plant maize ().
View Article and Find Full Text PDFMutations in Necroptosis-Related Genes Reported in Breast Cancer: A Cosmic and Uniport Database-Based Study.
Clin Breast Cancer
December 2024
Department of Experimental Medicine & Biotechnology, PGIMER, Chandigarh, India. Electronic address:
Breast cancer (BC) now holds the top position as the primary reason of cancer-related fatalities worldwide, overtaking lung cancer. BC is classified into diverse categories depending on histopathological type, hormone receptor status, and gene expression profile, with ongoing evolution in their classifications. Cancer initiates and advances when there is a disruption in cell death pathways.
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