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Factors Associated with Teenage Pregnancies During the Covid-19 Period in Pakwach District, Northern Uganda: A Case-Control Study.
Adolesc Health Med Ther
December 2024
Department of Community and Public Health, Busitema University, Mbale, Uganda.
Background: Teenage pregnancy rates have globally decreased over the years, but remain high, especially in low- and middle-income countries (LMICs). Among girls aged 15-19, teenage pregnancy remains the leading cause of death and a significant barrier to education and productivity. Its prevalence was high in pakwach district as reported by the DHO and police report during the pandemic.
View Article and Find Full Text PDFThe genomic secrets of invasive plants.
New Phytol
January 2025
School of Environment and Science, Griffith University, 170 Kessels Road, Nathan, Qld, 4111, Australia.
Genomics has revolutionised the study of invasive species, allowing evolutionary biologists to dissect mechanisms of invasion in unprecedented detail. Botanical research has played an important role in these advances, driving much of what we currently know about key determinants of invasion success (e.g.
View Article and Find Full Text PDFExploring cultural imaginaries of robots with children with brittle bone disease: a participatory design study.
Med Humanit
January 2025
School of Computer Science, The University of Sheffield, Sheffield, UK
A symbiotic relationship exists between narrative imaginaries of and real-life advancements in technology. Such cultural imaginings have a powerful influence on our understanding of the potential that technology has to affect our lives; as a result, narrative-based approaches to (PD) of technology are an active area of investigation.In this ongoing study, the following research questions are addressed: how can PD be optimised for the fields of robotics and assistive technology, particularly with regard to fostering empowerment and eliciting how people imagine the role of technology in their own futures? How can the symbiotic relationship between (popular) cultural imaginaries and real-life technological advancements be acknowledged within the PD process?The study synthesises fictional inquiry and science fiction prototyping methodologies and processes over multiple workshops.
View Article and Find Full Text PDFTowards a critical posthumanist perspective on participatory design.
Med Humanit
January 2025
English, University of Leeds, Leeds, UK.
Participatory design places a strong emphasis on human agency, user perspectives and democratic ideals of inclusivity and empowerment, and is therefore often associated with humanist principles and values. In contrast, critical posthumanism questions key humanist assumptions about the centred and singular nature of the 'human condition'. Instead, posthumanism points to the evolving and diverse lived experiences of people and how these are transformed by (and are transforming of) culture, environment and technology.
View Article and Find Full Text PDFBiophysical and Structural Features of αβT-Cell Receptor Mechanosensing: A Paradigmatic Shift in Understanding T-Cell Activation.
Immunol Rev
December 2024
Laboratory of Immunobiology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
αβT cells protect vertebrates against many diseases, optimizing surveillance using mechanical force to distinguish between pathophysiologic cellular alterations and normal self-constituents. The multi-subunit αβT-cell receptor (TCR) operates outside of thermal equilibrium, harvesting energy via physical forces generated by T-cell motility and actin-myosin machinery. When a peptide-bound major histocompatibility complex molecule (pMHC) on an antigen presenting cell is ligated, the αβTCR on the T cell leverages force to form a catch bond, prolonging bond lifetime, and enhancing antigen discrimination.
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