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Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions. | LitMetric

Methane attenuates myocardial ischemia injury in rats through anti-oxidative, anti-apoptotic and anti-inflammatory actions.

Free Radic Biol Med

Department of Navy Aviation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai 200433, People's Republic of China. Electronic address:

Published: January 2016

AI Article Synopsis

  • Myocardial infarction (MI) is a common and deadly cardiovascular condition, but methane-rich saline (MS) shows potential in providing heart protection due to its anti-oxidative, anti-inflammatory, and anti-apoptotic properties.
  • In experiments, the optimal dose of MS was found to be 10 mg/kg, which significantly reduced heart damage and improved cardiac function after MI in rats.
  • Overall, MS demonstrates a novel approach in treating ischemic heart diseases by minimizing heart tissue injury and preventing harmful changes in the heart's structure and function.

Article Abstract

Myocardial infarction (MI) remains the most frequent cardiovascular disease with high mortality. Recently, methane has been shown protective effects on small intestinal ischemia-reperfusion injury. We hypothesized that methane-rich saline (MS) could protect the myocardium again MI via its anti-oxidative, anti-apoptotic and anti-inflammatory effects. In experiment 1, tetrazolium chloride staining and detection of myocardial enzymes and oxidative and inflammatory parameters were performed at 12h after MI to determine the optimal dose at which intraperitoneal MS exerted the best protective effects on MI. In experiment 2, rats were treated with 10 ml/kg MS. Myocyte apoptosis was detected 72 h after MI, and cardiac function and myocardial remodeling were evaluated 4 weeks after MI. Results showed different dose of MS reduced infarct area, decreased myocardial enzymes, inhibited inflammation and oxidative stress following MI. The optimal dose of MS was 10 mg/kg. Moreover, treatment with 10mg/kg MS for 3 days significantly reduced myocyte apoptosis, improved cardiac function and inhibited myocardial remodeling (reduced anterior wall thickness, attenuated myocyte hypertrophy, and decreased myocardial collagen). MS protects the myocardium of MI rats via its anti-oxidative, anti-inflammatory, anti-apoptotic and anti-remodeling activities. Thus, MS provides a novel and promising strategy for the treatment of ischemic heart diseases.

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Source
http://dx.doi.org/10.1016/j.freeradbiomed.2015.11.017DOI Listing

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