Objective: A meta-analysis was performed to determine the association between P2X7-1513A/C polymorphism and pulmonary tuberculosis susceptibility.
Methods: Based on comprehensive searches of the MEDLINE, EMBASE and ISI Web of knowledge, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between P2X7-1513A/C polymorphism and pulmonary tuberculosis susceptibility.
Results: A total of 1916 cases and 2194 controls in 10 studies were pooled together for evaluation of the overall association between P2X7-1513A/C polymorphism and susceptibility of pulmonary tuberculosis. Allele model (A vs. C: p=0.15; OR=0.86, 95% CI=0.69-1.06), homozygous model (AA vs. CC: p=0.22; OR=0.78, 95% CI=0.53-1.16), and heterozygous model (AC vs. CC: p=0.23; OR=0.80, 95% CI=0.56-1.15) did not show decreased risk of developing pulmonary tuberculosis. Similarly, dominant model (AA+AC vs. CC: p=0.19; OR=0.80, 95% CI=0.56-1.12) and recessive model (AA vs. AC+CC: p=0.21; OR=0.85, 95% CI=0.66-1.10) failed to show decreased risk of developing pulmonary tuberculosis. In Indians, allele model (A vs. C: p=0.0006; OR=0.69, 95% CI=0.55-0.85), and recessive model (AA vs. AC+CC: p=0.0003; OR=0.62, 95% CI=0.48-0.80) indicated significant association between P2X7-1513A/C polymorphism and susceptibility to pulmonary tuberculosis.
Conclusions: Our pooled data suggest a association between P2X7-1513A/C polymorphism and the prevalence of pulmonary tuberculosis among Indian populations.
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