Methods for studying human organogenesis.

Differentiation

Department of Urology, University of California San Francisco, 400 Parnassus Avenue, Box A610, San Francisco, CA 94143, USA.

Published: September 2017

This review details methods for utilizing D & C suction abortus specimens as a source of human fetal organs to study the morphogenetic and molecular mechanisms of human fetal organ development. By this means it is possible to design experiments elucidating the molecular mechanisms of human fetal organ development and to compare and contrast human developmental mechanisms with that of laboratory animals. Finally human fetal organs can be grown in vivo as grafts to athymic mice, thus allowing ethical analysis of potential adverse effects of environmental toxicants.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4866906PMC
http://dx.doi.org/10.1016/j.diff.2015.10.005DOI Listing

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