Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jfo.2014.09.030 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Loss of Pigment Epithelium Derived Factor Sensitizes C57BL/6J Mice to Light-Induced Retinal Damage.
bioRxiv
December 2024
Department of Ophthalmology, Emory University, Atlanta, Georgia, United States.
Purpose: Pigment epithelium-derived factor (PEDF) is a neurotrophic glycoprotein secreted by the retinal pigment epithelium (RPE) that supports retinal photoreceptor health. Deficits in PEDF are associated with increased inflammation and retinal degeneration in aging and diabetic retinopathy. We hypothesized that light-induced stress in C57BL/6J mice deficient in PEDF would lead to increased retinal neuronal and RPE defects, impaired expression of neurotrophic factor Insulin-like growth factor 1 (IGF-1), and overactivation of Galectin-3-mediated inflammatory signaling.
View Article and Find Full Text PDFAssessing Preclinical Diabetic Retinopathy: The Role of Optical Coherence Tomography Angiography.
Cureus
October 2024
Ophthalmology, Kalinga Institute of Medical Sciences, Bhubaneswar, IND.
Article Synopsis
- The study aimed to analyze variations in retinal microvascular parameters in diabetic patients without retinopathy, those with nonproliferative diabetic retinopathy (NPDR), and healthy subjects using optical coherence tomography.
- It involved 68 eyes and assessed factors like capillary density, foveal avascular zone size, capillary dropout, and flow void areas, revealing significant differences between the groups.
- NPDR patients showed lower capillary density and larger FAZ areas than both No DR patients and controls, indicating distinct retinal changes associated with NPDR.
Validation of Inter-Reader Agreement/Consistency for Quantification of Ellipsoid Zone Integrity and Sub-RPE Compartmental Features Across Retinal Diseases.
Diagnostics (Basel)
October 2024
The Tony and Leona Campane Center for Excellence in Image-Guided Surgery and Advanced Imaging Research, Cleveland Clinic, Cleveland, OH 44195, USA.
Background: An unmet need exists when clinically assessing retinal and layer-based features of retinal diseases. Therefore, quantification of retinal-layer-thicknesses/fluid volumes using deep-learning-augmented platforms to reproduce human-obtained clinical measurements is needed.
Methods: In this analysis, 210 spectral-domain optical coherence tomography (SD-OCT) scans (30 without pathology, 60 dry age-related macular degeneration [AMD], 60 wet AMD, and 60 diabetic macular edema [total 23,625 B-scans]) were included.
Impact of transcranial Direct Current Stimulation on stereoscopic vision and retinal structure in adult amblyopic rodents.
Eye Brain
October 2024
Neuroprosthesis and Neuroengineering Research Group, Institute of Bioengineering (IB), University Miguel Hernández (UMH), Elche, 03020, Spain.
Purpose: The impact of visual deprivation on retinal structure is widely debated. Experimental models, like monocular deprivation through lid suture, provide insights into the consequences of lacking visual experience during development. This deprivation delays primary visual cortex (CV1) maturation due to improper neural connection consolidation, which remains plastic beyond the critical period.
View Article and Find Full Text PDFArticle Synopsis
- The study compares macular sensitivity and retinal thickness in long-term type 1 diabetes mellitus (DM1) patients without diabetic retinopathy (DR) over a 5-year period.
- Thirty-two eyes from DM1 patients were examined using microperimetry and spectral domain optical coherence tomography (SD-OCT), revealing significantly worse best corrected visual acuity (BCVA) in 2023 compared to 2018.
- Although macular sensitivity didn't change significantly, notable differences in macular integrity and retinal thickness, especially in the inner retinal layers, suggest that long-term DM1 patients can experience undetected retinal changes and functional decline despite not exhibiting DR symptoms.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!