AI Article Synopsis
- - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are serious skin reactions from drugs, leading to skin and mucosal issues, and have limited long-term studies on their complications.
- - A study analyzed 102 patients from 1998 to 2012 and found that the most common long-term complications were skin and eye problems, affecting 44.1% of patients.
- - Additionally, some patients faced severe organ issues, including chronic kidney disease and lung disease, while six patients developed autoimmune disorders such as Sjögren's syndrome and systemic lupus erythematosus.
Article Abstract
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. A limited number of studies have reported the long-term patterns of SJS and TEN complications in patient populations over long follow-up periods. The aim of this retrospective study was to collect data on long-term sequelae in patients admitted for SJS, SJS/TEN overlap, or TEN between 1998 and 2012. Among all 102 patients eligible for analysis, the 2 most common sequelae were cutaneous and ocular problems, both with incidences of 44.1%. Visceral organ involvement was observed in 2 patients with irreversible deterioration of chronic kidney disease and in one patient with interstitial lung disease. Autoimmune disease was present in 6 patients: Sjögren's syndrome or Sjögren-like syndrome in 5 patients and concomitant systemic lupus erythematosus and Hashimoto thyroiditis in one patient.
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| http://dx.doi.org/10.2340/00015555-2295 | DOI Listing |
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