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Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines. | LitMetric

Increased Expression of Serglycin in Specific Carcinomas and Aggressive Cancer Cell Lines.

Biomed Res Int

Biochemistry, Biochemical Analysis & Matrix Pathobiology Research Group, Laboratory of Biochemistry, Department of Chemistry, University of Patras, 26500 Patras, Greece.

Published: September 2016

AI Article Synopsis

  • The study focused on serglycin's presence in lung, breast, prostate, and colon cancers, revealing high levels of this protein in more aggressive cancer cell lines and tissues.
  • Aggressive cancer cells with KRAS or EGFR mutations were found to secrete serglycin at elevated levels, and an alternative splice variant of the protein was identified in some cell lines.
  • The research indicated that serglycin was more highly expressed in advanced tumors compared to normal tissue, suggesting it may play a significant role in cancer progression and the tumor microenvironment.

Article Abstract

In the present pilot study, we examined the presence of serglycin in lung, breast, prostate, and colon cancer and evaluated its expression in cell lines and tissues. We found that serglycin was expressed and constitutively secreted in culture medium in high levels in more aggressive cancer cells. It is worth noticing that aggressive cancer cells that harbor KRAS or EGFR mutations secreted serglycin constitutively in elevated levels. Furthermore, we detected the transcription of an alternative splice variant of serglycin lacking exon 2 in specific cell lines. In a limited number of tissue samples analyzed, serglycin was detected in normal epithelium but was also expressed in higher levels in advanced grade tumors as shown by immunohistochemistry. Serglycin staining was diffuse, granular, and mainly cytoplasmic. In some cancer cells serglycin also exhibited membrane and/or nuclear immunolocalization. Interestingly, the stromal cells of the reactive tumor stroma were positive for serglycin, suggesting an enhanced biosynthesis for this proteoglycan in activated tumor microenvironment. Our study investigated for first time the distribution of serglycin in normal epithelial and cancerous lesions in most common cancer types. The elevated levels of serglycin in aggressive cancer and stromal cells may suggest a key role for serglycin in disease progression.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637082PMC
http://dx.doi.org/10.1155/2015/690721DOI Listing

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