Context: Gestational thyrotoxicosis, whether associated with hyperemesis gravidarum or not, is thought to be due to excessive human chorionic gonadotropin (hCG) secretion.
Case Description: We report here the second case of gestational thyrotoxicosis associated with hyperemesis gravidarum due to a mutation of the TSH receptor, providing thyroid hypersensitivity to hCG.
Conclusion: Severe and lasting gestational thyrotoxicosis with normal hCG concentration should lead to sequencing of the TSH receptor gene.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1210/jc.2015-3670 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Obesity and postpartum hospital use among individuals without additional medical comorbidities.
Obesity (Silver Spring)
January 2025
Department of Obstetrics & Gynecology, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Objective: The objective of this study was to examine whether obesity without preexisting or gestational comorbidities is associated with postpartum hospital use (PHU).
Methods: We studied 2016 to 2018 birth certificate and discharge data on 178,729 New York City births without International Classification of Diseases, Tenth Revision (ICD-10) codes at delivery for diabetes; hypertension; placental disease; anemia; thyrotoxicosis; bariatric surgery; and pulmonary, cardiac, renal, bleeding, autoimmune, digestive, neuromuscular, mental, or substance-use disorders. We defined PHU as ≥1 readmission or emergency department visit within 30 days of delivery discharge.
Clinical Application of Thyrotropin Receptor Antibodies.
Horm Metab Res
December 2024
Department of Endocrinology and Metabolism, Lanzhou University Second Clinical Medical School, Lanzhou, China.
Thyrotropin receptor antibodies (TRAb) are specific for Graves' disease (GD) and play a crucial role in the pathogenesis of GD. TRAb assays have recently been greatly improved. This review discusses the clinical application of TRAb in the differential diagnosis of hyperthyroidism, the prognosis of GD, GD in gestation and pediatrics, and GD related ophthalmopathy (GO).
View Article and Find Full Text PDFAn unusual case of severe hyperbilirubinemia and thyrotoxicosis.
Endocr Regul
January 2024
Department of General Medicine, Baroda Medical College and SSG Hospital, Vadodara, India.
Article Synopsis
- - A 23-year-old pregnant woman experienced severe jaundice, anemia, dyspnea, and hyperthyroidism after five months of not menstruating.
- - Initial treatments for jaundice were ineffective, leading to a focus on managing her thyroid storm, a serious condition related to hyperthyroidism.
- - The patient's liver dysfunction improved significantly with the use of iodine and thionamides, highlighting a rare link between severe jaundice and thyroid storm during pregnancy.
Human chorionic gonadotropin (hCG) has structural similarities with thyroid-stimulating hormone (TSH) and may stimulate TSH receptors at higher concentrations. During pregnancy, placental hCG causes TSH suppression, contributing to hyperemesis. However, in males, clinical manifestations caused by excess hCG are rare.
View Article and Find Full Text PDFFrom Syncope to Pregnancy: A Case Report of Gestational Transient Thyrotoxicosis.
Cureus
September 2024
Department of Endocrinology, Diabetes, and Metabolism, Centro Hospitalar Universitário de Santo António, Unidade Local de Saúde de Santo António, Porto, PRT.
With a multifactorial etiology, syncope is a fairly common clinical presentation in emergency care. During pregnancy, it can result from hemodynamic and hormonal changes. One such rare cause is hyperthyroidism.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!