Gastric ulcers affect many people around the world and their development is a result of the imbalance between aggressive and protective factors in the gastric mucosa. Scutia buxifolia, commonly known as coronilha, has attracted the interest of the scientific community due to its pharmacological properties and its potential therapeutic applications. In this study, the preventive effects of the crude extract of Scutia buxifolia (ceSb) against gastric ulcer induced by 70% ethanol were evaluated in male Wistar rats. In addition, the composition of ceSb was clarified by high-performance liquid chromatography (HPLC). S. buxifolia extract (100, 200 and 400 mg/kg body weight) attenuated oxidative and histopathological features induced by ethanol. Moreover, all evaluated doses of ceSb caused significant (P<0.001 and P<0.0001) and dose-dependent increase in sulfhydryl groups (NPSH) levels, catalase (CAT) and superoxide dismutase (SOD) activities. Furthermore, the administration of ceSb reversed the increase in lipid peroxidation produced by ethanol. The protective effect of the extract could be attributed to antioxidant compounds present in the ceSb, such as flavonoids and phenolic acids, which were quantified by HPLC. Thus, an antioxidant effect of the extract leads to a protection on gastric tissue. These results indicate that S. buxifolia could have a beneficial role against ethanol toxicity by preventing oxidative stress and gastric tissue injury.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4629092 | PMC |
| http://dx.doi.org/10.1016/j.apsb.2014.05.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Fecal descriptor in honey: indole from a floral source as an explanation.
J Sci Food Agric
November 2022
Laboratorio de Biotecnología de Aromas, Facultad de Química, Universidad de la República, Montevideo, Uruguay.
Background: Animal odor, is one of the most common aroma defects described in the honey odor aroma wheel. It comprises two secondary descriptors: 'fecal' and 'cowshed'. However, the compounds responsible for these honey defects have not been fully identified.
View Article and Find Full Text PDFAlkaloids from the stem barks of Scutia buxifolia Reissek (Rhamnaceae): Structures and antimicrobial evaluation.
Phytochemistry
April 2022
Universidade Federal de Santa Maria, Departamento de Química, CEP, 97105-900, Santa Maria, RS, Brazil. Electronic address:
A reinvestigation of the chemical constituents of the stem barks of Scutia buxifolia, a member of the Rhamnaceae, resulted, along with the known alkaloids scutianine C and scutianene L, in the isolation of three undescribed diastereoisomeric alkaloids - scutianine N, 27-epi-scutianine N and 3, 4, 7-tri-epi-scutianine N -, one undescribed non macrocyclic alkaloid - scutianine Q - and a neutral compound -scutianene M. Their structures were determined using extensive NMR techniques and HRMS. The absolute configurations of the stereogenic centers of the three diastereoisomeric alkaloids have been assigned by gas chromatography employing modified cyclodextrins as chiral stationary phases.
View Article and Find Full Text PDFStructure of the style and pollen tube pathway in the Ziziphoid and Rhamnoid clades of Rhamnaceae.
Protoplasma
March 2018
Facultad de Agronomía, Departamento de Recursos Naturales y Ambiente, Universidad de Buenos Aires, Cátedra de Botánica General. Av. San Martín 4453 (1417), Buenos Aires, Argentina.
The ultrastructure of the style and pollen tube pathway before, during and after anthesis were studied in 13 species belonging to the tribes Pomaderreae, Paliureae, Colletieae and Gouanieae (Ziziphoid clade) and Rhamneae (Rhamnoid clade) using light microscopy and transmission electron microscopy. The aim of this study is to provide new morphological characters useful for phylogenetic analysis at suprageneric level in Rhamnaceae. The patterns of pollen tube growth and the ultrastructural changes undergone by cells of the style were also described.
View Article and Find Full Text PDFTopical antiedematogenic and anti-inflammatory effect of Scutia buxifolia Reissek gel and stability study.
J Photochem Photobiol B
February 2017
Graduate Program in Biological Sciences: Toxicological Biochemistry, Federal University of Santa Maria, Camobi Campus, Santa Maria, RS 97105-900, Brazil.
Scutia buxifolia Reissek (Rhamnaceae), popularly known in Brazil as "coronilha", is a plant species used in folk medicine for several disorders, including inflammation. However, no studies have been done with this species to confirm its topical anti-inflammatory action. In this study we evaluate the topical antiedematogenic and anti-inflammatory effects of the gel containing crude extract (CE) and the gel containing ethyl acetate (EtOAc) fraction of S.
View Article and Find Full Text PDFAntinociceptive and anti-inflammatory effect of the Scutia buxifolia Reissek stem barks extract.
Phytomedicine
September 2016
Graduate Program in Pharmaceutical Sciences, Health Sciences Centre, Federal University of Santa Maria, Santa Maria, RS, Brazil. Electronic address:
Background: Scutia buxifolia (Rhamnaceae) has been extensively studied for its phenolics groups, which are able to capture free radicals; being therefore, considered promising as an antioxidant in preventing diseases resulting from oxidative stress.
Hypothesis: Scutia buxifolia extract (SBE) presents antinociceptive and anti-inflammatory effect in mice.
Study Design: SBE (400-800mg/kg) was tested in different pain models to investigate its antinociceptive and anti-inflammatory action.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!