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Hyperuricemia suppresses lumican, exacerbating adverse remodeling after myocardial infarction by promoting fibroblast phenotype transition.
J Transl Med
October 2024
Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, China.
Background: Hyperuricemia is independently associated with a poor prognosis in patients with myocardial infarction (MI). Furthermore, MI induces activation of the repair response in local fibroblasts, resulting in extracellular matrix accumulation that generates a stable fibrotic scar in the infarcted area. However, researchers have not determined whether hyperuricemia affects fibroblast activation and its involvement in postinfarction cardiac remodeling.
View Article and Find Full Text PDFRelationship of urate-lowering drugs with cognition and dementia: A Mendelian randomization and observational study.
Arch Gerontol Geriatr
February 2025
Department of Pharmacy, Second Affiliated Hospital, Fujian Medical University, Quanzhou, China. Electronic address:
Prior studies have presented paradoxical results regarding the association of uric acid-lowering drugs (ULDs) therapy with cognition and dementia. We aimed to explore this correlation. In this observational study, we extracted and analyzed the data from the National Health and Nutrition Examination Survey (NHANES) database and the FDA Adverse Event Reporting System (FAERS) database to investigate the association of ULDs with cognitive function and dementia.
View Article and Find Full Text PDFCardiovascular Outcomes of Uric Acid Lowering Medications: A Meta-Analysis.
Curr Cardiol Rep
December 2024
Department of Cardiovascular Medicine, Heart, Vascular and Thoracic Institute, Cleveland Clinic, 9500 Euclid Avenue, Desk J1-5, Cleveland, OH, 44195, USA.
Article Synopsis
- - The study analyzed cardiovascular outcomes related to uric acid-lowering medications, finding no significant benefits for xanthine oxidase inhibitors (XOI) compared to placebo in terms of major cardiovascular events.
- - The meta-analysis included 47 studies with over 3.8 million patients, showing that while there was no substantial difference in cardiovascular risks with XOI, Febuxostat may lower the risk of heart failure compared to Allopurinol.
- - The researchers concluded that further studies are needed to confirm these findings, particularly the potential heart failure benefits of Febuxostat and the overall ineffectiveness of XOI in reducing cardiovascular events.
Modulation of cutaneous vasodilation by reactive oxygen species during local and whole body heating in young and older adults.
Am J Physiol Regul Integr Comp Physiol
December 2024
Human and Environmental Physiology Research Unit, School of Human Kinetics, University of Ottawa, Ottawa, Ontario, Canada.
We evaluated reactive oxygen species (ROS) modulation of cutaneous vasodilation during local and whole body passive heating in young and older adults. Cutaneous vascular conductance normalized to maximum vasodilation (%CVC) was assessed in young and older adults (10/group) using laser-Doppler flowmetry at four dorsal forearm sites treated with ) Ringer solution (control), ) 100 µM apocynin (NADPH oxidase inhibitor), ) 10 µM allopurinol (xanthine oxidase inhibitor), or ) 10 µM tempol (superoxide dismutase mimetic), via intradermal microdialysis during local () and whole body heating (). In , forearm skin sites were set at 33°C during baseline and then progressively increased to 39°C and 42°C (30 min each).
View Article and Find Full Text PDFIntroduction: Smoking poses a risk to flap viability, with nicotine being a major contributor to the formation of free radicals. Allopurinol, known for its antioxidant properties, has been shown to enhance tissue survival in ischemic conditions by reducing the production of reactive oxygen species (ROS). This study aims to assess the impact of allopurinol on the viability and success of skin flaps in Wistar rats exposed to nicotine.
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