A randomized clinical study was conducted in order to compare the effectiveness of norfloxacin and cinoxacin in complicated urinary tract infections. Norfloxacin proved effective in 80% of the 40 patients treated, cinoxacin in only 60%.
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Prioritization, sources, and ecological risk of typical antibiotics in the Huai River, a Chinese major river: a warning about aquaculture.
Environ Sci Pollut Res Int
May 2023
Anhui Provincial Engineering Laboratory of Water and Soil Pollution Control and Remediation, School of Ecology and Environment, Anhui Normal University, Wuhu, Anhui, 241002, People's Republic of China.
This is the first comprehensive report on antibiotics in the Huai River, a major Chinese river. To illuminate the concentrations, prioritization, spatial distributions, sources, and ecological risks of antibiotics, surface water samples were collected and three types of most widely used antibiotics (16 sulfonamides, 8 tetracyclines, and 14 quinolones) were analyzed. The results indicated that concentrations of ∑quinolones (86 ± 31 ng/L) > ∑tetracyclines (20 ± 13 ng/L) > ∑sulfonamides (11 ± 3.
View Article and Find Full Text PDFStoichiometry-Selective Antagonism of α4β2 Nicotinic Acetylcholine Receptors by Fluoroquinolone Antibiotics.
ACS Chem Neurosci
June 2022
Division of Biosciences, University College London, London WC1E 6BT, United Kingdom.
Quinolone antibiotics disrupt bacterial DNA synthesis by interacting with DNA gyrase and topoisomerase IV. However, in addition, they have been shown to act as inhibitors of pentameric ligand-gated ion channels such as GABA receptors and the α7 nicotinic acetylcholine receptor (nAChR). In the present study, we have examined the effects of quinolone antibiotics on the human α4β2 nAChR, an important subtype that is widely expressed in the central nervous system.
View Article and Find Full Text PDFQuantitation of fluoroquinolones in honey using tandem mass spectrometry (LC-MS/MS): nested validation with two mass spectrometers.
J AOAC Int
December 2010
Canadian Food Inspection Agency, 3650 36th St NW, Calgary, AB, T2L 2L1, Canada.
A number of drugs in the quinolone and fluoroquinolone families, approved for veterinary treatment of food animals by various countries, may be used to treat bee diseases and thereby contaminate honey. An LC-MS/MS method has been developed for the quantification of the quinolones: flumequine, nalidixic acid, oxolinic acid, and pipemidic acid; and the fluoroquinolones ciprofloxacin, danofloxacin, difloxacin, enrofloxacin, norfloxacin, ofloxacin, orbifloxacin, marbofloxacin, sarafloxacin, and sparfloxacin. A method-matched calibration curve is used with several internal standards, i.
View Article and Find Full Text PDFSimultaneous determination of eleven quinolones in animal feed by liquid chromatography with fluorescence and ultraviolet absorbance detection.
J Chromatogr A
November 2009
Istituto Zooprofilattico Sperimentale dell'Umbria e delle Marche, I-06126 Perugia, Italy.
A rapid and simple multi-residue procedure is described for assaying eleven quinolones (cinoxacin, ciprofloxacin, danofloxacin, difloxacin, enrofloxacin, flumequine, marbofloxacin, nalidixic acid, norfloxacin, oxolinic acid and sarafloxacin) in feeds at sub-additive levels (1-5 mg kg(-1)). Five grams of sample were extracted by a metaphosphoric acid/acetonitrile mixture (70/30, v/v) and purified onto OASIS HLB cartridges. The determination was achieved by liquid chromatography (LC) using a GEMINI C18 analytical column both with fluorescence detection (FD) and photodiode-array (DAD).
View Article and Find Full Text PDFTrace analysis of quinolone and fluoroquinolone antibiotics from wastewaters by liquid chromatography-electrospray tandem mass spectrometry.
J Chromatogr A
December 2008
College of Urban and Environmental Sciences, Peking University, Beijing 100871, China.
A sensitive liquid chromatography-electrospray tandem mass spectrometry method, combined with solid-phase extraction and a weak cation exchange cartridge cleanup, was established for twenty quinolone and fluoroquinolone antibiotics (pipemidic acid, flerofloxacin, ofloxacin, pefloxacin, enoxacin, norfloxacin, ciprofloxacin, danofloxacin, enrofloxacin, lomefloxacin, difloxacin, sarafloxacin, gatifloxacin, sparfloxacin, moxifloxacin, cinoxacin, oxolinic acid, nalidixic acid, flumequine, and piromidic acid) in influent, effluent, and river waters. For the various water matrices considered, the overall recoveries were from 64% to 127% except for piromidic acid (27-33%), and no obvious matrix effect was observed. The method detection limits for the twenty target antibiotics in the influent, effluent, and surface water samples were 1.
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