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Exploring the role of multimodal [F]F-PSMA-1007 PET/CT and multiparametric MRI data in predicting ISUP grading of primary prostate cancer.
Eur J Nucl Med Mol Imaging
January 2025
The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, China.
Purpose: The study explores the role of multimodal imaging techniques, such as [F]F-PSMA-1007 PET/CT and multiparametric MRI (mpMRI), in predicting the ISUP (International Society of Urological Pathology) grading of prostate cancer. The goal is to enhance diagnostic accuracy and improve clinical decision-making by integrating these advanced imaging modalities with clinical variables. In particular, the study investigates the application of few-shot learning to address the challenge of limited data in prostate cancer imaging, which is often a common issue in medical research.
View Article and Find Full Text PDFGenetic coupling of enhancer activity and connectivity in gene expression control.
Nat Commun
January 2025
MRC Laboratory of Medical Sciences, London, UK.
Gene enhancers often form long-range contacts with promoters, but it remains unclear if the activity of enhancers and their chromosomal contacts are mediated by the same DNA sequences and recruited factors. Here, we study the effects of expression quantitative trait loci (eQTLs) on enhancer activity and promoter contacts in primary monocytes isolated from 34 male individuals. Using eQTL-Capture Hi-C and a Bayesian approach considering both intra- and inter-individual variation, we initially detect 19 eQTLs associated with enhancer-eGene promoter contacts, most of which also associate with enhancer accessibility and activity.
View Article and Find Full Text PDFThe rapid acquisition of projective images with low radiation dose is essential in computed tomography with diffraction enhanced imaging to extract absorption, refraction, and scattering images from weakly absorbing specimens. This plays a critical role in applying diffraction enhanced imaging to biological and medical imaging. In this study, an improved diffraction enhanced imaging method is proposed to rapidly implement X-ray trimodal computed tomography.
View Article and Find Full Text PDFThe impact of age on the efficacy of radiotherapy in pleural mesothelioma patients receiving trimodality therapy: a population-based study of the SEER database.
J Thorac Dis
October 2024
Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital, Sichuan University, Chengdu, China.
Article Synopsis
- Pleural mesothelioma (PM) is a serious cancer with poor survival rates, and this study explores how age affects the effectiveness of additional radiotherapy after surgery and chemotherapy.
- A case-control study analyzed data from 745 PM patients, showing that those aged 50 to 64 benefited significantly from additional radiotherapy, with improved overall and cancer-specific survival compared to those receiving only surgery and chemotherapy.
- The results suggest that patients aged 50 to 64 may gain from trimodality therapy, while patients younger than 50 and older than 65 did not show significant benefits from the additional treatment.
Eligibility and Endpoints for Clinical Trials in Trimodality Therapy for Bladder Cancer.
Bladder Cancer
October 2024
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Background: Trimodality therapy (TMT) is a viable option for muscle-invasive localized bladder cancer, providing an alternative to radical cystectomy in properly selected patients. The approval of novel therapeutics in different stages of bladder cancer treatment has sparked interest in exploring concurrent systemic therapies with radiation in clinical trials to enhance long-term outcomes. Achieving uniformity in trial eligibility criteria and endpoint definitions is imperative in describing clinical significance, comparing trials, and changing standard of care guidelines.
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