[Implementation Plan for Two Clinical Practice Guides (CPGs) Contained in the Integral Care Guides (ICGs) of the General System of Social Health Care in Colombia: A) "Early Detection of Depressive Episode and Recurrent Depressive Disorder in Adults. Integral Attention of Adults with Diagnosis of Depressive Episode or Recurrent Depressive Disorder (CPG-Depression)". B) "Early Detection, Diagnosis and Treatment of the Acute Intoxication Phase In 18-Years-Old Patients with Alcohol Abuse or Dependence (CPG-Alcohol)"].

Introduction: Clinical practice guides (CPGs) are systematically recommended, with the best clinical evidence available, to help physicians and patients in decision-making concerning the most adequate sanitary care as well as the selection of the best diagnostic and therapeutic options when facing a health problem or a clinical condition. After obtaining these recommendations, it is crucial to adopt them in daily clinical practice; the process through which this change is sought is known as implementation. This document contains recommendations for implementing CPGs in two psychiatric pathologies: 1) depressive episode and recurrent depressive disorder in adults, and 2) acute intoxication phase in cases of alcohol abuse or dependence.

Methodology: The recommended implementation process is described; besides, barriers and facilitators found in the two guides, together with the list of management indicators and clinical outcomes, are identified for their monitoring within the General Health Social Security System of Colombia.

Conclusion: CPGs contain recommendations with the best clinical evidence available. The challenge is achieving the adoption of such tool by users, being therefore necessary to follow the diffusion, dissemination and implementation plan, overcoming barriers and resorting to intrinsic and extrinsic facilitators for CPGs as well as performing monitoring with indicators described for measuring the implementation process (management indicators) and the effect of CPGs in clinical practice (indicators of clinical outcome.).