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Frequencies of spontaneous breast development and spontaneous menarche in Turner syndrome in Japan. | LitMetric

AI Article Synopsis

  • - Analysis of the Growject® database revealed that out of 212 Turner syndrome patients treated with growth hormone (GH), spontaneous breast development occurred in 36.3% and spontaneous menarche in 14.6%.
  • - The study found lower rates of spontaneous breast development in patients with the 45,X karyotype, while those with structural abnormalities of the second X chromosome had higher rates.
  • - There were no significant differences in spontaneous puberty rates between two different GH dosage groups, indicating that GH treatment does not enhance the likelihood of experiencing spontaneous puberty.

Article Abstract

The Growject® database on human GH treatment in Turner syndrome was analyzed in the Turner Syndrome Research Collaboration, and the relationships of the frequencies of spontaneous breast development and spontaneous menarche with karyotype and GH treatment were investigated. One hundred and three cases started GH treatment with 0.5 IU/kg/ week (0.5 IU group), and their dose was increased to 0.35 mg/kg/wk midway through the treatment course. Another 109 cases started GH at a dose of 0.35 mg/kg/wk (0.35 mg group). Spontaneous breast development was observed in 77 (36.3%) of the 212 patients, and spontaneous menarche occurred in 31 patients (14.6%). The frequency of spontaneous breast development was significantly lower in patients with the 45,X karyotype and significantly higher in patients with a structural abnormality of the second X chromosome. The frequency of spontaneous menarche was significantly higher in patients with mosaicism characterized by X monosomy and a cellular line with no structural abnormality of the X chromosome. No significant differences in frequencies of spontaneous breast development and spontaneous menarche were observed between the two dose groups, indicating that GH treatment does not increase the frequency of spontaneous puberty.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4628951PMC
http://dx.doi.org/10.1297/cpe.24.167DOI Listing

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