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New Insights via RNA Profiling of Formalin-Fixed Paraffin-Embedded Lung Tissue of Pulmonary Fibrosis Patients.
Int J Mol Sci
November 2023
Interstitial Lung Diseases Center of Excellence, Department of Pulmonology, St. Antonius Hospital, 3435 CM Nieuwegein, The Netherlands.
In sporadic idiopathic pulmonary fibrosis (sIPF) and pulmonary fibrosis caused by a mutation in telomere (TRG-PF) or surfactant related genes (SRG-PF), there are a number of aberrant cellular processes known that can lead to fibrogenesis. We investigated whether RNA expression of genes involved in these processes differed between sIPF, TRG-PF, and SRG-PF and whether expression levels were associated with survival. RNA expression of 28 genes was measured in lung biopsies of 26 sIPF, 17 TRG-PF, and 6 SRG-PF patients.
View Article and Find Full Text PDFOutcome of lung transplantation for adults with interstitial lung disease associated with genetic disorders of the surfactant system.
ERJ Open Res
November 2023
Department of Respiratory Medicine and Lung Transplantation, Assistance Publique - Hôpitaux de Marseille, Hôpital Nord; Aix-Marseille Université, Marseille, France.
Background: Interstitial lung disease associated with genetic disorders of the surfactant system is a rare entity in adults that can lead to lung transplantation. Our objective was to describe the outcome of these patients after lung transplantation.
Methods: We conducted a retrospective, multicentre study, on adults who underwent lung transplantation for such disease in the French lung transplant centres network, from 1997 to 2018.
[Interstitial lung diseases in children of genetic origin].
Rev Mal Respir
January 2023
Service de pneumologie pédiatrique, centre de référence des maladies respiratoires rares RespiRare, hôpital Armand Trousseau, Sorbonne université, AP-HP, 75012 Paris, France; Inserm, UMR_S933, laboratoire des maladies génétiques d'expression pédiatriques, hôpital Armand Trousseau, Sorbonne université, 75012 Paris, France. Electronic address:
Interstitial lung diseases in children of genetic origin. Interstitial lung disease (ILD) in children (chILD) encompasses a heterogeneous group of rare respiratory disorders, most of which are chronic and severe. In more and more of these cases, a genetic cause has been identified.
View Article and Find Full Text PDFThe Genetic and Epigenetic Footprint in Idiopathic Pulmonary Fibrosis and Familial Pulmonary Fibrosis: A State-of-the-Art Review.
Diagnostics (Basel)
December 2022
Respiratory Unit, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, 20142 Milan, Italy.
Idiopathic pulmonary fibrosis (IPF) is a rare disease of the lung with a largely unknown etiology and a poor prognosis. Intriguingly, forms of familial pulmonary fibrosis (FPF) have long been known and linked to specific genetic mutations. There is little evidence of the possible role of genetics in the etiology of sporadic IPF.
View Article and Find Full Text PDFA novel prognostic model for prostate cancer based on androgen biosynthetic and catabolic pathways.
Front Oncol
November 2022
Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China.
Prostate cancer (PCa) is one of the most common malignancies in males globally, and its pathogenesis is significantly related to androgen. As one of the important treatments for prostate cancer, androgen deprivation therapy (ADT) inhibits tumor proliferation by controlling androgen levels, either surgically or pharmacologically. However, patients treated with ADT inevitably develop biochemical recurrence and advance to castration-resistant prostate cancer which has been reported to be associated with androgen biosynthetic and catabolic pathways.
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