AI Article Synopsis
- The nucleolus acts as a stress sensor, suggesting that rDNA regulation may impact cellular aging and longevity.
- Using diverse industrial yeasts and advanced genetic techniques, researchers explored how chromosome balance is affected during cell passages and alcohol stress, indicating a relationship with rDNA levels.
- The study also established connections between cellular processes like redox balance, DNA stability, and the functioning of telomeres and the nucleolus, highlighting the dynamic nature of yeast genomes.
Article Abstract
The nucleolus is considered to be a stress sensor and rDNA-based regulation of cellular senescence and longevity has been proposed. However, the role of rDNA in the maintenance of genome integrity has not been investigated in detail. Using genomically diverse industrial yeasts as a model and array-based comparative genomic hybridization (aCGH), we show that chromosome level may be balanced during passages and as a response to alcohol stress that may be associated with changes in rDNA pools. Generation- and ethanol-mediated changes in genes responsible for protein and DNA/RNA metabolism were revealed using next-generation sequencing. Links between redox homeostasis, DNA stability, and telomere and nucleolus states were also established. These results suggest that yeast genome is dynamic and chromosome homeostasis may be controlled by rDNA.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4825570 | PMC |
| http://dx.doi.org/10.1080/15384101.2015.1093705 | DOI Listing |
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