AI Article Synopsis
- The study aimed to test if RIP (Rationale Ischemic Preconditioning) speeds up fracture healing in rats.
- Rats underwent a treatment involving a pneumatic tourniquet applied for a specific duration to the fractured limb.
- Results showed that the RIP group had more mature callus after one week compared to controls, indicating enhanced healing, although some serum levels showed no significant differences over time.
Article Abstract
Purpose: We hypothesized that RIP accelerates fracture healing.
Methods: Rats (n = 48) were used for the technique of ischemic preconditioning involved applying 35 min of intermittent pneumatic tourniquet for 7 cycles of 5 min each to the fractured hind limb.
Results: We observed greater callus maturity in RIP group at first week after fracture when compared to controls (p < 0,0001). The serum MDA levels demonstrated statistically lower values at the RIP group at the first week after fracture; however, there were not significant differences at 3rd and 5th weeks (p = 0.0001, p = 0.725, p = 0.271, respectively).
Conclusions: Greater callus maturity was obtained in RIP group.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602003 | PMC |
| http://dx.doi.org/10.1016/j.jor.2015.05.020 | DOI Listing |
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