While entropy changes are the usual subject of fluctuation theorems, we seek fluctuation relations involving time-symmetric quantities, namely observables that do not change sign if the trajectories are observed backward in time. We find detailed and integral fluctuation relations for the (time-integrated) difference between entrance rate and escape rate in mesoscopic jump systems. Such inflow rate, which is even under time reversal, represents the discrete-state equivalent of the phase-space contraction rate. Indeed, it becomes minus the divergence of forces in the continuum limit to overdamped diffusion. This establishes a formal connection between reversible deterministic systems and irreversible stochastic ones, confirming that fluctuation theorems are largely independent of the details of the underling dynamics.
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Alzheimers Dement
December 2024
Texas A&M University, College Station, TX, USA.
Background: Older females, particularly susceptible to Alzheimer's disease (AD), may be affected by hormonal fluctuation during life. We aim to investigate the relationship between changes in brain volume and sex steroid hormones over time. We hypothesize that levels of sex hormones (17ß-estradiol, progesterone, and testosterone) relate to changes in brain volume, especially in the hippocampus (HPC) and cerebellum (CB).
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December 2024
University of Kentucky, Lexington, KY, USA.
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View Article and Find Full Text PDFAlzheimers Dement
December 2024
Sapienza University of Rome, Rome, Italy.
Background: Parkinson's disease and Huntington's disease are both neurodegenerative conditions involving the basal ganglia area of the brain. Both conditions can cause symptoms that affect movement. Cognitive decline or dementia can also occur in both.
View Article and Find Full Text PDFPhys Rev Lett
December 2024
Department of Physics, Princeton University, Princeton, New Jersey 08544, USA.
Measuring bipartite fluctuations of a conserved charge, such as the particle number, is a powerful approach to understanding quantum systems. When the measured region has sharp corners, the bipartite fluctuation receives an additional contribution known to exhibit a universal angle dependence in 2D isotropic and uniform systems. Here we establish that, for generic lattice systems of interacting particles, the corner charge fluctuation is directly related to quantum geometry.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.
Background: Loneliness is associated with lower cognitive function and may increase dementia risk. However, it is unclear if this effect is mediated by depression. Resolving this issue is important to design effective interventions to promote healthy aging.
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