BH3 domain mimetics based on the small protein scyllatoxin (ScTx) were designed to target the anti-apoptotic protein Bcl2 in vitro. Intrinsically disordered ScTx variants were found to bind Bcl2 with nanomolar affinity, indicating that an induced fit binding mechanism is required for favorable BH3 : Bcl2 interaction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1039/c5ob02080h | DOI Listing |
Publication Analysis
Top Keywords
bh3 domain
8
domain mimetics
8
targeting anti-apoptotic
4
anti-apoptotic bcl2
4
bcl2 proteins
4
proteins scyllatoxin-based
4
scyllatoxin-based bh3
4
mimetics bh3
4
mimetics based
4
based small
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!