Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642988 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143156 | PLOS |
Publication Analysis
Top Keywords
Similar Publications
Correction: Siu et al. Hexokinase 2 Regulates Ovarian Cancer Cell Migration, Invasion and Stemness via FAK/ERK1/2/MMP9/NANOG/SOX9 Signaling Cascades. 2019, , 813.
Cancers (Basel)
October 2024
Department of Obstetrics and Gynecology, University of Hong Kong, Hong Kong, China.
In the original publication [...
View Article and Find Full Text PDFCorrigendum: A role for TRPC3 in mammalian testis development.
Front Cell Dev Biol
October 2024
Sex Development Laboratory, Hudson Institute of Medical Research, Melbourne, VIC, Australia.
[This corrects the article DOI: 10.3389/fcell.2024.
View Article and Find Full Text PDFActivation of PERK/eIF2α/ATF4/CHOP branch of endoplasmic reticulum stress response and cooperation between HIF-1α and ATF4 promotes Daprodustat-induced vascular calcification.
Front Pharmacol
July 2024
MTA-DE Lendület Vascular Pathophysiology Research Group, Research Centre for Molecular Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.
Article Synopsis
- - Vascular calcification in chronic kidney disease (CKD) patients increases cardiovascular risks, and the drug Daprodustat (DPD) accelerates this calcification while treating anemia associated with CKD by activating the HIF-1 pathway.
- - DPD treatment enhances markers indicating hypoxia, ER stress, and osteogenic differentiation in both CKD mice and human vascular cells, leading to increased calcification in aorta and kidneys.
- - The study reveals that DPD induces ER stress via the ATF4 pathway, with the potential to mitigate its pro-calcification effects by targeting ATF4 in therapies.
Unveiling the roles of Sertoli cells lineage differentiation in reproductive development and disorders: a review.
Front Endocrinol (Lausanne)
May 2024
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
In mammals, gonadal somatic cell lineage differentiation determines the development of the bipotential gonad into either the ovary or testis. Sertoli cells, the only somatic cells in the spermatogenic tubules, support spermatogenesis during gonadal development. During embryonic Sertoli cell lineage differentiation, relevant genes, including , , , , , , , and , are expressed at specific times and in specific locations to ensure the correct differentiation of the embryo toward the male phenotype.
View Article and Find Full Text PDFReprograming skin fibroblasts into Sertoli cells: a patient-specific tool to understand effects of genetic variants on gonadal development.
Biol Sex Differ
March 2024
Institute for Clinical and Translational Science, University of California, Irvine, CA, USA.
Background: Disorders/differences of sex development (DSD) are congenital conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. With overlapping phenotypes and multiple genes involved, poor diagnostic yields are achieved for many of these conditions. The current DSD diagnostic regimen can be augmented by investigating transcriptome/proteome in vivo, but it is hampered by the unavailability of affected gonadal tissue at the relevant developmental stage.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!