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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4642983 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143269 | PLOS |
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Associations of Central Arterial Stiffness With Brain White Matter Integrity and Gray Matter Volume in MRI Across the Adult Lifespan.
J Magn Reson Imaging
January 2025
Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Background: Central arterial stiffening is associated with brain white matter (WM) damage and gray matter (GM) volume loss in older adults, but little is known about this association from an adult lifespan perspective.
Purpose: To investigate the associations of central arterial stiffness with WM microstructural organization, WM lesion load, cortical thickness, and GM volume in healthy adults across the lifespan.
Study Type: This is a cross-sectional study.
Bone marrow transplantation reverses metabolic alterations in multiple sulfatase deficiency: a case series.
Commun Med (Lond)
January 2025
Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN, USA.
Background: Multiple sulfatase deficiency (MSD) is an exceptionally rare neurodegenerative disorder due to the absence or deficiency of 17 known cellular sulfatases. The activation of all these cellular sulfatases is dependent on the presence of the formylglycine-generating enzyme, which is encoded by the SUMF1 gene. Disease-causing homozygous or compound heterozygous variants in SUMF1 result in MSD.
View Article and Find Full Text PDFDiagnostic Accuracy of Low-Dose Myocardial Perfusion Imaging in a Real-World Setting.
J Nucl Cardiol
January 2025
Université de Lorraine, CHRU-Nancy, Department of Nuclear Medicine and Nancyclotep Imaging Platform, F-54000, Nancy, France; Université de Lorraine, INSERM U1254, IADI, F-54000 Nancy, France. Electronic address:
Background: This large-scale study analyzes factors affecting diagnostic accuracy of low-dose myocardial perfusion imaging and correlation with coronary angiography in a real-world practice.
Methods: We compared data extracted from routine reports of (i) low-dose [Tc]sestamibi stress-MPI performed with no attenuation correction and predominantly exercise stress testing and (ii) the corresponding coronary angiography.
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Background: White matter hyperintensities (WMH) were reported to contribute to the thinning of regional cortex connected to WMH in cerebral small vessel disease. However, the relationship between WMH and regional changes in WMH‐connected cortex in Alzheimer’s disease (AD) remains unclear. The objective of this study is to investigate the association between WMH and regional cortical thickness, amyloid and tau deposition, and synaptic density changes in the WMH‐connected cortex.
View Article and Find Full Text PDFLocal disruptions in non‐rapid eye movement sleep expression are associated with cerebrovascular pathology and worse memory performance in older adults.
Alzheimers Dement
December 2024
Department of Psychiatry and Human Behavior, University of California, Irvine, Irvine, CA, USA
Background: Aging is associated with disruptions in non‐rapid eye movement (NREM) sleep and memory decline. Cerebral small vessel disease (CSVD) increases with age and is associated with clinical sleep disturbance, but little is known about its relationship with local expression of NREM sleep. Here, we explore associations between CSVD burden, memory, and local electroencephalography (EEG) measures during NREM sleep in older adults.
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