Rather than concentrate on a single topic, this feature issue presents the wide variety of research in optics that takes place at a single institution, the United States Naval Research Laboratory (NRL) and is analogous to an NRL feature issue published in Applied Optics in 1967. NRL is the corporate research laboratory for the Navy and Marine Corps. It conducts a broadly based multidisciplinary program of scientific research and advanced technological development in the physical, engineering, space, and environmental sciences related to maritime, atmospheric, and space domains. NRL's research is directed toward new and improved materials, techniques, equipment, and systems in response to identified and anticipated Navy needs. A number of articles in this issue review progress in broader research areas while other articles present the latest results on specific topics.
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http://dx.doi.org/10.1364/AO.54.00NRL1 | DOI Listing |
Cell Rep
March 2025
National Key Laboratory of Immunity & Inflammation, Department of Pathogen Biology, Naval Medical University, Shanghai 200433, China. Electronic address:
Alveolar macrophages (AMs) are crucial for lung homeostasis, and their dysfunction causes uncontrolled fibrotic responses and pulmonary disorders. Protein phosphatases control multiple cellular events. However, whether nuclear phosphatases cooperate with histone modifiers to affect pulmonary fibrosis progress remains obscure.
View Article and Find Full Text PDFJ Cancer Res Clin Oncol
March 2025
Department of Laboratory Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, China.
Background And Objective: Hepatocellular carcinoma (HCC) is one of the malignancies with increasing incidence globally, and microvascular invasion (MVI) is a crucial determinant of prognosis in patients. This study aimed to investigate platelet distribution width (PDW) and diabetes mellitus as indicators for predicting preoperative MVI in HCC, providing more accurate predictive tools for clinicians to guide treatment strategies and improve patient survival and quality of life.
Methods: A retrospective study was conducted, including 1357 patients who underwent hepatectomy for HCC between January 2008 and December 2014 at the Eastern Hepatobiliary Surgery Hospital in China.
EClinicalMedicine
March 2025
National Heart and Lung Institute, Imperial College London, London, UK.
Background: Bronchodilator responsiveness testing is mainly used for diagnosing asthma. We aimed to investigate whether it is associated with progression to chronic airflow obstruction over time.
Methods: The multinational Burden of Obstructive Lung Disease cohort study surveyed adults, aged 40 years and above, at baseline and followed them up after a mean of 9.
Exp Mol Med
March 2025
Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Histone lysine succinylation, an emerging epigenetic marker, has been implicated in diverse cellular functions, yet its role in cancer drug resistance is not well understood. Here we investigated the genome-wide alterations in histone 3 lysine 23 succinylation (H3K23su) and its impact on gene expression in 5-fluorouracil (5-FU)-resistant HCT15 colon cancer cells. We utilized CUT&Tag assays to identify differentially enriched regions (DERs) of H3K23su in 5-FU-resistant HCT15 cells via integration with ATAC-seq and RNA sequencing data.
View Article and Find Full Text PDFLaryngoscope
March 2025
ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Objective: The objectives of this study were to observe the differences between the left and right eyes in healthy individuals during binocular video head impulse testing (vHIT) and to identify the optimal eye for a more precise evaluation of the vestibulo-ocular reflex (VOR) gain.
Materials And Methods: This is a prospective two-center study involving 41 healthy individuals. All participants included in the study underwent binocular vHIT, which was performed by experienced technicians.
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