Human herpesvirus 6A (HHV-6A) U14 is a virion protein with little known function in virus propagation. Here, we elucidated its function by constructing and analyzing U14-mutated viruses. We found that U14 is essential for HHV-6A propagation. We then constructed a mutant virus harboring dysfunctional U14. This virus showed severely reduced growth and retarded maturation. Taken together, these data indicate that U14 plays an important role during HHV-6A maturation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4719638 | PMC |
| http://dx.doi.org/10.1128/JVI.02492-15 | DOI Listing |
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