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Population aging has become a prevalent societal trend in the 21st century, giving rise to intricate challenges for healthcare systems. Taiwan is expected to become a "super-aging society" in 2025. In 2020, the Health Promotion Administration, referencing World Health Organization (WHO) guidelines on integrated care for older people (ICOPE), began promoting person-centered functional assessments for older adults to prevent and delay disability, reduce reliance on formal healthcare, and promote healthy aging, aging in place, and active aging.
View Article and Find Full Text PDFAccelerating evidence generation: Addressing critical challenges and charting a path forward.
J Clin Transl Sci
October 2024
Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Duke University Medical Center, Durham, NC, USA.
Efficient evidence generation to assess the clinical and economic impact of medical therapies is critical amid rising healthcare costs and aging populations. However, drug development and clinical trials remain far too expensive and inefficient for all stakeholders. On October 25-26, 2023, the Duke Clinical Research Institute brought together leaders from academia, industry, government agencies, patient advocacy, and nonprofit organizations to explore how different entities and influencers in drug development and healthcare can realign incentive structures to efficiently accelerate evidence generation that addresses the highest public health needs.
View Article and Find Full Text PDFA strategic approach to evaluating battery innovation investments.
iScience
November 2024
Office of Energy Research & Development, Natural Resources Canada, Ottawa, ON K1A 0E4, Canada.
Driven predominantly by public and private innovation, rechargeable batteries have, over a few decades, graduated from powering luxury consumer electronics to becoming one of the linchpins of the energy transition. Rapid adoption trends of batteries must accelerate to meet global net-zero targets for mobility and stationary storage, and will require making sound investments in battery innovation that deliver the most value. Because battery innovation is increasingly complex, multi-disciplinary, and subject to the coordination of stakeholders across academia, industry, government, and the broader public, building common and intuitive frameworks for understanding becomes critical to making progress.
View Article and Find Full Text PDFYuragi biomarker concept for evaluating human induced pluripotent stem cells using heterogeneity-based Raman finger-printing.
Biophys Physicobiol
March 2024
Department of Stem Cell Biology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima 734-8553, Japan.
Considering the fundamental mechanism causing singularity phenomena, we performed the following abduction: Assuming that a multicellular system is driven by spontaneous fluctuation of each cell and dynamic interaction of the cells, state transition of the system would be experimentally predictable from cellular heterogeneity. This study evaluates the abductive hypothesis by analyzing cellular heterogeneity to distinguish pre-state of state transition of differentiating cells with Raman spectroscopy and human induced pluripotent stem cells (hiPSCs) technique. Herein, we investigated the time development of cellular heterogeneity in Raman spectra during cardiomyogenesis of six hiPSC lines and tested two types of analyses for heterogeneity.
View Article and Find Full Text PDFThe art of establishing mineral tolerances of dogs and cats.
J Anim Sci
January 2024
Chief Medical Officer, Hill's Pet Nutrition, Topeka, KS, USA.
For over six decades, nutritional science has provided well-developed, peer-reviewed nutrient recommendations to support the health of dogs and cats. These guidelines are updated based on new scientifically valid research and appropriate peer-review. Recent regulatory and scientific positions around health issues have resulted in strong opinions and desires for rapid regulatory action surrounding mineral nutrition, but with limited and conflicting scientific evidence.
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