AI Article Synopsis
- The study investigates if hypertensive disorders during pregnancy increase the risk of Alzheimer's disease (AD) in women.
- The research involved a case-control approach with surveys conducted among women with and without AD, achieving an 85.2% response rate.
- While no overall link was found between the two groups regarding pregnancy complications, early-onset AD patients reported hypertensive issues more frequently than those with late-onset AD.
Article Abstract
Background: After hypertensive disorders of pregnancy, more subjective cognitive complaints and white matter lesions are reported compared to women after normal pregnancies. Both have a causal relationship with Alzheimer's disease (AD).
Aim: To investigate if women whose pregnancy was complicated by hypertensive disorders have an increased risk of AD.
Methods: A case-control study in women with AD from the Alzheimer Center of the VU University Medical Center Amsterdam and women without AD. Paper and telephone surveys were performed.
Results: The response rate was 85.2%. No relation between women with (n = 104) and without AD (n = 129) reporting pregnancies complicated by hypertensive disorders (p = 0.11) was found. Women with early-onset AD reported hypertensive disorders of pregnancy more often (p = 0.02) compared to women with late-onset AD.
Conclusion: A reported history of hypertensive disorders of pregnancy appears not to be associated with AD later in life.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637816 | PMC |
| http://dx.doi.org/10.1159/000439043 | DOI Listing |
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