AI Article Synopsis
- A study indicates that the CD36 glycoprotein is involved in oral fat sensing and may contribute to obesity development, especially given lower CD36 expression in some obese individuals.
- The research focused on young Algerian teenagers, finding that obese teens had higher thresholds for detecting oleic acid compared to their lean counterparts.
- Additionally, a specific genetic variant (rs1761667 polymorphism) of the CD36 gene was more common in obese teens, suggesting a link between this genetic factor and obesity.
Article Abstract
Growing number of evidences have suggested that oral fat sensing, mediated by a glycoprotein CD36 (cluster of differentiation 36), plays a significant role in the development of obesity. Indeed, a decreased expression of CD36 in some obese subjects is associated with high dietary fat intake. In the present study, we examined whether an increase in body mass index (BMI) is associated with altered oleic acid lingual detection thresholds and blood lipid profile in young Algerian teenagers (n = 165). The obese teenagers (n = 83; 14.01 ± 0.19 years; BMI z-score 2.67 ± 0.29) exhibited higher lingual detection threshold for oleic acid than lean participants (n = 82, 13.92 ± 0.23 years; BMI z-score 0.03 ± 0.0001). We also studied the association between rs1761667 polymorphism of CD36 gene and obesity. The AA and AG genotypes were more frequent in obese teenagers, whereas GG genotype was more common in lean participants. The A-allele frequency was higher in obese teenagers than that in lean children. We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663583 | PMC |
| http://dx.doi.org/10.3390/nu7115455 | DOI Listing |
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